QuickView for PPP2CA;jsessionid=29B527B51E0E4028284AD0F5A3445B55;jsessionid=48958C8EB5923FECBF81C09296D74B6E;jsessionid=2057581D34CEA2DE570E8CE1EEB232A8;jsessionid=076C2AFDEB08BB0808590C1CC2824F9E (gene)
- Gene Symbol:
- Ppp2ca
Rattus norvegicus - Full name:
- protein phosphatase 2, catalytic subunit, alpha isozyme
- Synonyms:
- Pp2a1, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform, protein phosphatase 2, catalytic subunit, alpha isoform, protein phosphatase 2a, catalytic subunit, alpha isoform, protein phosphatase-2A-alpha
- Genomic Location:
- Chr 10: 37621256-37641008
- Description:
-
catalyzes the removal of serine- and threonine- bound phosphate groups
- Orthologs:
- Homo sapiens , Mus musculus , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-125 , Predicted Gene Targets for miR-133 , Predicted Gene Targets for miR-139 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-141 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-219 , Predicted Gene Targets for miR-188 , Predicted Gene Targets for miR-29
GO Molecular Function
protein serine/threonine phosphatase activity | kinase binding | beta-2 adrenergic receptor binding | GABA receptor binding | protein phosphatase 2A binding | cation binding | protein kinase binding | protein kinase B binding | enzyme binding | protein-containing complex binding | phosphatase activity | signaling receptor binding | hydrolase activity | adrenergic receptor binding | catalytic activity | ion channel binding | protein domain specific binding | cytoskeletal protein binding | tau protein binding | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | protein heterodimerization activity | antigen binding | ion binding | protein binding | protein phosphatase binding | protein dimerization activity | phosphoric ester hydrolase activity | G-protein coupled receptor binding | phosphatase binding | metal ion binding | protein antigen binding | protein C-terminus binding
GO Biological Process
protein serine/threonine phosphatase activity | negative regulation of phosphorylation | negative regulation of intracellular transport | regulation of cysteine-type endopeptidase activity | regulation of dephosphorylation | regulation of intracellular protein transport | protein dephosphorylation | positive regulation of microtubule binding | response to cytokine | cellular response to glucose stimulus | regulation of cellular localization | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | response to hormone | positive regulation of phosphoprotein phosphatase activity | negative regulation of cellular process | regulation of phosphatase activity | negative regulation of RNA biosynthetic process | response to metal ion | regulation of protein import | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | glucose homeostasis | positive regulation of phosphate metabolic process | response to antibiotic | positive regulation of dephosphorylation | cellular process | cellular homeostasis | negative regulation of protein import into nucleus | mesoderm development | negative regulation of nucleic acid-templated transcription | protein heterotrimerization | positive regulation of protein kinase activity | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular component organization | negative regulation of protein localization to nucleus | cellular response to metal ion | positive regulation of protein binding | phosphatase activity | response to stimulus | negative regulation of protein transport | negative regulation of epithelial to mesenchymal transition | regulation of cellular protein localization | positive regulation of protein metabolic process | positive regulation of peptidase activity | negative regulation of intracellular protein transport | response to peptide | positive regulation of cysteine-type endopeptidase activity | response to glucose | positive regulation of phosphatase activity | negative regulation of transporter activity | reproduction | cellular response to inorganic substance | response to alcohol | positive regulation of proteolysis | cellular response to toxic substance | cellular response to ethanol | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | cellular component assembly | protein modification process | regulation of peptide transport | macromolecule modification | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | positive regulation of protein dephosphorylation | regulation of intracellular transport | response to ethanol | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of phosphate metabolic process | cellular response to antibiotic | multicellular organism development | cellular glucose homeostasis | cellular response to peptide hormone stimulus | regulation of peptidase activity | phosphorus metabolic process | response to follicle-stimulating hormone | protein complex oligomerization | cellular response to insulin stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of cellular protein localization | regulation of gene expression | response to lipid | cellular response to peptide | cell cycle | regulation of protein autophosphorylation | cellular response to gonadotropin stimulus | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of protein localization to nucleus | phosphoprotein phosphatase activity | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | negative regulation of ion transmembrane transport | cellular response to cytokine stimulus | negative regulation of calcium ion transmembrane transporter activity | regulation of cellular protein metabolic process | negative regulation of ion transport | positive regulation of endopeptidase activity | regulation of calcium ion transmembrane transport | response to toxic substance | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | cellular response to drug | regulation of microtubule binding | regulation of cellular metabolic process | regulation of protein kinase activity | protein trimerization | negative regulation of calcium ion transport | regulation of protein metabolic process | heart development | homeostatic process | response to monosaccharide | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of signaling receptor activity | protein-containing complex assembly | protein metabolic process | regulation of establishment of protein localization | cardiac ventricle development | positive regulation of protein modification process | cellular response to calcium ion | response to organic substance | regulation of protein import into nucleus | regulation of protein dephosphorylation | regulation of kinase activity | response to insulin | anatomical structure development | metabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular response to carbohydrate stimulus | chemical homeostasis | positive regulation of cell death | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | cellular response to steroid hormone stimulus | regulation of ion transmembrane transport | positive regulation of binding | response to gonadotropin | cellular response to follicle-stimulating hormone stimulus | negative regulation of protein metabolic process | meiotic cell cycle | regulation of cell communication | dephosphorylation | negative regulation of molecular function | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | cellular protein metabolic process | protein heterooligomerization | regulation of endopeptidase activity | regulation of developmental process | regulation of ion transport | regulation of phosphoprotein phosphatase activity | developmental process | regulation of calcium ion transport | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | response to organonitrogen compound | regulation of epithelial to mesenchymal transition | cardiac chamber development | response to lead ion | response to calcium ion | positive regulation of metabolic process | regulation of calcium ion transmembrane transporter activity | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to carbohydrate | response to steroid hormone | circulatory system development | carbohydrate homeostasis | negative regulation of cell differentiation | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | synapse | catalytic complex | neuron projection | chromosome, centromeric region | cell | distal axon | terminal bouton | cytoplasm | spindle | intracellular organelle | presynapse | protein-containing complex | cell projection | postsynapse | plasma membrane | postsynaptic density | microtubule cytoskeleton | asymmetric synapse | protein phosphatase type 2A complex | spindle pole | protein serine/threonine phosphatase complex | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | axon terminus | cell periphery | axon | neuron projection terminus | cytosol | cytoskeleton | intracellular | membrane
