QuickView for PRKCA;jsessionid=9840EA03F7C5B5AFAF8D8769FEB9FCFD;jsessionid=F0AC9A80A34214067F6058F8392CF153 (gene)
- Gene Symbol:
- Prkca
Rattus norvegicus - Full name:
- protein kinase C, alpha
- Synonyms:
- Pkca, protein kinase C alpha type, PKC-A, PKC-alpha
- Genomic Location:
- Chr 10: 97366773-97625118
- Description:
-
displays Ca+2 dependent protein kinase activity
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-150 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-326 , Predicted Gene Targets for miR-369-3p , Predicted Gene Targets for miR-539 , Predicted Gene Targets for miR-9 , Predicted Gene Targets for miR-203 , Predicted Gene Targets for miR-362
GO Molecular Function
histone threonine kinase activity | calcium-dependent protein kinase activity | cation binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | protein kinase C activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | calcium-dependent protein serine/threonine kinase activity | purine nucleotide binding | calcium-dependent protein kinase C activity | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | protein binding | zinc ion binding | histone kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | transition metal ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | histone kinase activity (H3-T6 specific) | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | cell morphogenesis | regulation of muscle system process | negative regulation of cellular response to insulin stimulus | positive regulation of locomotion | negative regulation of MAPK cascade | histone threonine kinase activity | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | cell motility | neuron projection morphogenesis | intracellular signal transduction | regulation of synapse assembly | regulation of localization | induction of positive chemotaxis | regulation of programmed cell death | peptidyl-amino acid modification | establishment of localization | regulation of immune system process | response to hormone | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | histone modification | cell differentiation | positive regulation of epithelial cell proliferation | nervous system development | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | calcium-dependent protein kinase activity | generation of neurons | response to antibiotic | blood vessel morphogenesis | regulation of bone remodeling | cellular process | regulation of glucose import | regulation of cell motility | central nervous system neuron axonogenesis | localization | cellular homeostasis | cell projection morphogenesis | chromatin organization | negative regulation of signaling | neuron development | central nervous system neuron differentiation | response to estradiol | regulation of platelet aggregation | macromolecule localization | regulation of chemotaxis | regulation of response to osmotic stress | negative regulation of apoptotic process | response to corticosterone | regulation of cell cycle | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | granulocyte chemotaxis | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | cell junction assembly | intrinsic apoptotic signaling pathway | regulation of platelet activation | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | inactivation of MAPK activity | positive regulation of cellular protein metabolic process | cellular component organization | calcium ion homeostasis | positive regulation of epithelial cell migration | regulation of vasculature development | response to stimulus | peptidyl-threonine phosphorylation | vasculature development | cell morphogenesis involved in neuron differentiation | neutrophil chemotaxis | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | negative regulation of protein kinase activity | posttranscriptional regulation of gene expression | regulation of cell proliferation | tube morphogenesis | regulation of blood circulation | negative regulation of glucose transmembrane transport | response to peptide | protein serine/threonine kinase activity | programmed cell death | protein kinase C activity | negative regulation of transporter activity | response to alcohol | cardiovascular system development | negative regulation of transport | positive regulation of blood vessel endothelial cell migration | negative regulation of metabolic process | cellular component assembly | regulation of wound healing | protein modification process | cartilage development | regulation of synapse structure or activity | regulation of cell adhesion | macromolecule modification | negative regulation of transmembrane transport | cell chemotaxis | metal ion homeostasis | blood vessel development | response to ethanol | leukocyte migration | positive regulation of macrophage differentiation | positive regulation of exocytosis | locomotion | response to nitrogen compound | central nervous system neuron development | apoptotic process | system development | chondrocyte differentiation | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | learning or memory | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | negative regulation of glucose import | regulation of phosphorylation | regulation of receptor-mediated endocytosis | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | positive regulation of chemotaxis | axon development | positive regulation of secretion | response to ketone | response to lipid | nervous system process | positive regulation of dense core granule biogenesis | desmosome assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | regulation of anion channel activity | regulation of blood coagulation | calcium-dependent protein serine/threonine kinase activity | regulation of synapse organization | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | negative regulation of insulin receptor signaling pathway | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | response to corticosteroid | regulation of cellular component movement | response to oxidative stress | regulation of the force of heart contraction | axonogenesis | positive regulation of cell differentiation | regulation of endothelial cell migration | positive regulation of myeloid cell differentiation | cognition | positive regulation of cell migration | negative regulation of ion transmembrane transport | calcium-dependent protein kinase C activity | regulation of cellular protein metabolic process | histone H3-T6 phosphorylation | angiogenesis | phosphorylation | negative regulation of ion transport | response to toxic substance | regulation of heart contraction | protein phosphorylation | cell morphogenesis involved in differentiation | cation homeostasis | phosphate-containing compound metabolic process | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | desmosome organization | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | negative regulation of MAP kinase activity | histone phosphorylation | positive regulation of synapse assembly | positive regulation of transport | apoptotic signaling pathway | negative regulation of anion channel activity | regulation of mitotic cell cycle | neuron differentiation | protein metabolic process | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | response to organic substance | regulation of homotypic cell-cell adhesion | regulation of hemopoiesis | histone kinase activity | regulation of kinase activity | regulation of lipopolysaccharide-mediated signaling pathway | response to mechanical stimulus | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of exocytosis | peptidyl-serine autophosphorylation | anatomical structure development | cell projection organization | metabolic process | cell-cell junction assembly | response to mineralocorticoid | regulation of body fluid levels | negative regulation of programmed cell death | positive regulation of lipopolysaccharide-mediated signaling pathway | regulation of bone resorption | cellular response to carbohydrate stimulus | regulation of tissue remodeling | negative regulation of heart contraction | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | behavior | cell adhesion | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | connective tissue development | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of glucose transmembrane transport | animal organ development | response to reactive oxygen species | regulation of endothelial cell proliferation | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of ERK1 and ERK2 cascade | ion homeostasis | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | regulation of ion transmembrane transport | negative regulation of translation | establishment of protein localization | positive regulation of endothelial cell migration | negative regulation of glial cell apoptotic process | positive regulation of MAPK cascade | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of epithelial cell migration | regulation of response to wounding | regulation of cell communication | regulation of blood vessel endothelial cell migration | regulation of macrophage differentiation | negative regulation of molecular function | negative regulation of signal transduction | signaling | covalent chromatin modification | response to organic cyclic compound | cell development | regulation of endocytosis | regulation of transmembrane transporter activity | protein localization | regulation of epithelial cell proliferation | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | positive regulation of tissue remodeling | regulation of nervous system development | regulation of developmental process | regulation of ion transport | kinase activity | developmental process | organelle organization | peptidyl-serine phosphorylation | cellular protein modification process | histone kinase activity (H3-T6 specific) | tube development | regulation of transport | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of bone resorption | response to organonitrogen compound | cellular metal ion homeostasis | regulation of anion transport | central nervous system development | positive regulation of metabolic process | chromosome organization | skeletal system development | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | regulation of translation | negative regulation of cell death | neutrophil migration | circulatory system development | regulation of inflammatory response | aging | chemotaxis | divalent inorganic cation homeostasis | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | response to glucocorticoid | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | positive regulation of positive chemotaxis | regulation of phosphorus metabolic process
GO Cellular Component
non-motile cilium | dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | organelle membrane | cell body | cell | neuronal cell body | plasma membrane protein complex | cytoplasm | intracellular organelle | endoplasmic reticulum | membrane microdomain | dendritic tree | apical part of cell | protein-containing complex | cell projection | endomembrane system | plasma membrane | cilium | membrane raft | photoreceptor outer segment | perinuclear region of cytoplasm | mitochondrion | 9+0 non-motile cilium | photoreceptor cell cilium | membrane-bounded organelle | nucleus | organelle | alphav-beta3 integrin-PKCalpha complex | mitochondrial envelope | cell periphery | axon | mitochondrial membrane | cytosol | intracellular | membrane
