QuickView for PRKCB;jsessionid=FB2DAD4E23703243139B57364653F434;jsessionid=D9761C9DE8AED3438DC8431008D82EA9;jsessionid=2BC8547722C00C5C3F7352AD7F662726;jsessionid=C391CFE074B15BC70EED41B9A822F116 (gene)

Gene Symbol:

PRKCB Homo sapiens

Full name:

protein kinase C beta

Synonyms:

PKC-beta, PKCB, PRKCB1, PRKCB2, protein kinase C beta type, PKC-B, protein kinase C, beta 1 polypeptide

Genomic Location:

Chr 16: 23754823-24139063

Description:

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbo...

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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  OCT1_05 ,  STAT4_01 ,  GAGCCTG_MIR484 ,  OCT1_04 ,  STAT6_02 ,  ATTACAT_MIR3803P ,  GCANCTGNY_MYOD_Q6 ,  TCCGTCC_MIR184 ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  HEB_Q6 ,  TCF4_Q5 ,  OCT1_Q6 ,  CATTTCA_MIR203 ,  GTCTTCC_MIR7 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  NFY_Q6 ,  RNGTGGGC_UNKNOWN ,  AP4_Q6_01 ,  TGCTTTG_MIR330 ,  CAGCTG_AP4_Q5

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-184 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-203

Cytogenetic Map:

16p12.2-p12.1

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