QuickView for PTEN;jsessionid=03F711E8072E2B18E5C30563CC600722;jsessionid=519B67DFAD3FF0F254208CEAA1B1F776;jsessionid=301F6C6D53E5283F40D780C43A7A8912;jsessionid=075A08CF316613E87B09F0D320AA8730 (gene)
- Gene Symbol:
- Pten
Mus musculus - Full name:
- phosphatase and tensin homolog
- Synonyms:
- 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, PTENbeta, TEP1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, mitochondrial PTENalpha, mutated in multiple advanced cancers 1
- Genomic Location:
- Chr 19: 32832067-32900650
- Description:
-
This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Dele...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , OCT1_01 , OCT1_04 , OCT1_05 , OCT1_Q6 , OCT_C , GFI1_01 , OCT1_B , POU3F2_02 , CEBPDELTA_Q6
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-186 , Predicted Gene Targets for miR-193 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-216 , Predicted Gene Targets for miR-22 , Predicted Gene Targets for miR-26 , Predicted Gene Targets for miR-30-3p , Predicted Gene Targets for miR-542-3p , Predicted Gene Targets for miR-188 , Predicted Gene Targets for miR-29
GO Molecular Function
protein serine/threonine phosphatase activity | phosphatidylinositol bisphosphate phosphatase activity | kinase binding | protein kinase binding | platelet-derived growth factor receptor binding | enzyme binding | protein-containing complex binding | inositol phosphate phosphatase activity | phosphatase activity | anaphase-promoting complex binding | protein tyrosine/serine/threonine phosphatase activity | phosphatidylinositol trisphosphate phosphatase activity | signaling receptor binding | hydrolase activity | phosphatidylinositol monophosphate phosphatase activity | ubiquitin-specific protease binding | protein tyrosine phosphatase activity | catalytic activity | protein domain specific binding | phosphoprotein phosphatase activity | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | hydrolase activity, acting on ester bonds | identical protein binding | phosphatidylinositol phosphate phosphatase activity | protein tyrosine kinase binding | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | protein binding | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | phosphatidylinositol-3-phosphatase activity | phosphoric ester hydrolase activity | PDZ domain binding | growth factor receptor binding | protease binding | glutamate receptor binding | ionotropic glutamate receptor binding
GO Biological Process
protein serine/threonine phosphatase activity | phosphatidylinositol bisphosphate phosphatase activity | negative regulation of signaling receptor activity | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | brain development | negative regulation of excitatory postsynaptic potential | cell morphogenesis | regulation of cell cycle process | cellular response to decreased oxygen levels | dendritic spine development | negative regulation of MAPK cascade | protein dephosphorylation | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | developmental process involved in reproduction | regulation of cellular localization | muscle tissue development | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | protein stabilization | regulation of localization | regulation of cell cycle G1/S phase transition | prostate gland growth | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | regulation of cell aging | negative regulation of phagocytosis | hippocampus development | phosphatidylinositol metabolic process | forebrain morphogenesis | response to hormone | negative regulation of potassium ion transport | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | social behavior | regulation of heart growth | regulation of cardiac muscle cell apoptotic process | cell differentiation | negative regulation of adherens junction organization | negative regulation of dendrite development | negative regulation of cell-matrix adhesion | negative regulation of organ growth | nervous system development | positive regulation of protein catabolic process | response to drug | organ growth | organophosphate catabolic process | negative regulation of protein phosphorylation | epithelial cell migration | cell part morphogenesis | regulation of G1/S transition of mitotic cell cycle | neurogenesis | polyol metabolic process | positive regulation of phosphate metabolic process | prepulse inhibition | generation of neurons | membrane organization | response to antibiotic | membrane biogenesis | phospholipid metabolic process | blood vessel morphogenesis | regulation of cardiac muscle cell proliferation | positive regulation of neurological system process | cellular process | negative regulation of muscle organ development | negative regulation of axonogenesis | organic substance catabolic process | regulation of cell motility | central nervous system neuron axonogenesis | regulation of dendritic spine morphogenesis | localization | axon ensheathment | cell projection morphogenesis | positive regulation of synaptic transmission | regulation of ubiquitin-protein transferase activity | negative regulation of signaling | developmental growth | negative regulation of axon regeneration | negative regulation of synapse organization | chemical synaptic transmission | neuron development | negative regulation of G1/S transition of mitotic cell cycle | negative regulation of developmental growth | central nervous system neuron differentiation | reproductive system development | synapse assembly | canonical Wnt signaling pathway | dendritic spine organization | epithelium migration | multicellular organismal reproductive process | regulation of striated muscle tissue development | negative regulation of apoptotic process | endomembrane system organization | response to hypoxia | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | myelin maintenance | regulation of neuron projection development | positive regulation of muscle cell apoptotic process | central nervous system myelination | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of neurological system process | regulation of cell differentiation | inositol phosphate catabolic process | regulation of lymphocyte apoptotic process | negative regulation of cell motility | negative regulation of wound healing | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | gliogenesis | catabolic process | positive regulation of ubiquitin protein ligase activity | phosphorylated carbohydrate dephosphorylation | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | inositol phosphate phosphatase activity | cellular component organization | cellular lipid metabolic process | negative regulation of cell morphogenesis involved in differentiation | urogenital system development | phosphatase activity | head development | negative regulation of cardiac muscle tissue development | positive regulation of cellular protein catabolic process | response to stimulus | maternal behavior | protein tyrosine/serine/threonine phosphatase activity | vasculature development | cell morphogenesis involved in neuron differentiation | negative regulation of epithelial to mesenchymal transition | phosphatidylinositol trisphosphate phosphatase activity | regulation of mitotic cell cycle phase transition | oligodendrocyte development | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | negative regulation of cell adhesion | postsynaptic density assembly | cellular response to hypoxia | negative regulation of neurological system process | response to stress | negative regulation of dendritic spine morphogenesis | endothelial cell migration | negative regulation of protein kinase activity | alcohol metabolic process | regulation of cell proliferation | negative regulation of neuron projection development | regulation of protein ubiquitination | tube morphogenesis | response to peptide | cardiac muscle tissue development | regulation of cell cycle phase transition | ensheathment of neurons | circadian rhythm | axon ensheathment in central nervous system | programmed cell death | phosphatidylinositol monophosphate phosphatase activity | positive regulation of proteolysis involved in cellular protein catabolic process | negative regulation of transporter activity | reproduction | response to alcohol | cardiovascular system development | rhythmic process | positive regulation of proteolysis | cellular response to toxic substance | cellular response to ethanol | regulation of neuron projection regeneration | negative regulation of transport | negative regulation of muscle tissue development | regulation of phagocytosis | brain morphogenesis | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | regulation of wound healing | negative regulation of potassium ion transmembrane transport | protein modification process | regulation of synapse structure or activity | modulation of chemical synaptic transmission | regulation of cell adhesion | presynaptic membrane assembly | macromolecule modification | cell-cell signaling | negative regulation of ERK1 and ERK2 cascade | negative regulation of transmembrane transport | protein tyrosine phosphatase activity | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | response to ethanol | regulation of nucleic acid-templated transcription | regulation of potassium ion transmembrane transport | regulation of membrane potential | regulation of cellular response to stress | locomotion | organic hydroxy compound metabolic process | response to nitrogen compound | central nervous system neuron development | apoptotic process | protein kinase B signaling | organelle assembly | cellular response to hormone stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | response to oxygen levels | nitrogen compound metabolic process | alcohol catabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | Wnt signaling pathway | negative regulation of growth | modulation of excitatory postsynaptic potential | regulation of protein stability | negative regulation of phosphate metabolic process | myelination | cellular response to antibiotic | regulation of adherens junction organization | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of synaptic transmission, GABAergic | cellular response to peptide hormone stimulus | negative regulation of dendritic spine development | regulation of MAPK cascade | phosphorus metabolic process | learning or memory | regulation of axonogenesis | cellular response to insulin stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | plasma membrane organization | telencephalon development | regulation of neuron differentiation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | rhythmic synaptic transmission | platelet-derived growth factor receptor signaling pathway | axon development | rhythmic behavior | cellular response to stress | nervous system process | cellular response to peptide | membrane assembly | synaptic signaling | negative regulation of cyclin-dependent protein serine/threonine kinase activity | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | negative regulation of smooth muscle cell proliferation | phosphoprotein phosphatase activity | cellular response to oxygen levels | regulation of myelination | regulation of synapse organization | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | small molecule metabolic process | cellular carbohydrate metabolic process | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | regulation of cellular component movement | synapse organization | axonogenesis | positive regulation of cell differentiation | cognition | negative regulation of ribosome biogenesis | synapse maturation | negative regulation of ion transmembrane transport | central nervous system myelin maintenance | negative regulation of dendrite morphogenesis | negative regulation of epithelial cell migration | negative regulation of protein kinase B signaling | locomotory behavior | regulation of cellular protein metabolic process | inositol phosphate dephosphorylation | negative regulation of cell-substrate adhesion | glial cell differentiation | angiogenesis | negative regulation of ion transport | regulation of synaptic vesicle clustering | parental behavior | carbohydrate metabolic process | startle response | response to toxic substance | phosphatidylinositol phosphate phosphatase activity | regulation of apoptotic signaling pathway | cell morphogenesis involved in differentiation | postsynapse assembly | phosphate-containing compound metabolic process | regulation of B cell apoptotic process | regulation of potassium ion transmembrane transporter activity | cellular response to drug | negative regulation of response to wounding | regulation of muscle cell apoptotic process | striated muscle tissue development | negative regulation of cardiac muscle cell proliferation | positive regulation of extrinsic apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | presynaptic membrane organization | regulation of protein kinase activity | dentate gyrus development | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of striated muscle tissue development | heart development | lipid modification | limbic system development | positive regulation of cell proliferation | regulation of protein phosphorylation | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | negative regulation of vascular smooth muscle cell proliferation | regulation of mitotic cell cycle | regulation of potassium ion transport | long term synaptic depression | positive regulation of molecular function | neuron differentiation | multicellular organism reproduction | presynapse assembly | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | regulation of signaling receptor activity | negative regulation of cyclin-dependent protein kinase activity | multicellular organismal response to stress | regulation of cell morphogenesis involved in differentiation | negative regulation of epithelial cell proliferation | protein metabolic process | cellular response to insulin-like growth factor stimulus | negative regulation of wound healing, spreading of epidermal cells | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | negative regulation of cell projection organization | phosphatidylinositol dephosphorylation | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | phosphatidylinositol-3-phosphatase activity | regulation of focal adhesion assembly | response to leptin | response to insulin | anatomical structure development | regulation of dendrite morphogenesis | cell surface receptor signaling pathway | positive regulation of neurogenesis | reproductive behavior | negative regulation of endocytosis | cell projection organization | metabolic process | positive regulation of cell development | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | developmental maturation | negative regulation of programmed cell death | mating behavior | negative regulation of cell size | negative regulation of mitotic cell cycle | oligodendrocyte differentiation | regulation of vesicle-mediated transport | behavior | positive regulation of cell death | regulation of myeloid cell apoptotic process | dendritic spine morphogenesis | neuron projection development | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | mating | neuron-neuron synaptic transmission | cell death | animal organ development | forebrain development | negative regulation of neuron differentiation | pallium development | negative regulation of cellular protein metabolic process | negative regulation of synaptic vesicle clustering | negative regulation of cellular component movement | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | regulation of phosphate metabolic process | negative regulation of potassium ion transmembrane transporter activity | positive regulation of TRAIL-activated apoptotic signaling pathway | regulation of ion transmembrane transport | negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | negative regulation of cell aging | regulation of postsynapse organization | positive regulation of MAPK cascade | positive regulation of excitatory postsynaptic potential | regulation of axon regeneration | dendrite morphogenesis | anatomical structure formation involved in morphogenesis | positive regulation of cardiac muscle cell apoptotic process | excitatory synapse assembly | negative regulation of cell cycle | memory | adult behavior | negative regulation of protein metabolic process | regulation of dendrite development | regulation of epithelial cell migration | regulation of response to wounding | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | dephosphorylation | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | regulation of dendritic spine development | signaling | regulation of transcription, DNA-templated | glial cell development | neuromuscular process | cell development | regulation of endocytosis | regulation of developmental growth | regulation of transmembrane transporter activity | regulation of epithelial cell proliferation | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | anatomical structure morphogenesis | prostate gland development | regulation of organ growth | reproductive structure development | dendrite development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | negative regulation of neuron projection regeneration | glycerophospholipid metabolic process | developmental process | organelle organization | cellular protein modification process | negative regulation of focal adhesion assembly | tube development | regulation of cell junction assembly | regulation of transport | negative regulation of cell proliferation | peptidyl-tyrosine dephosphorylation | circadian behavior | response to organonitrogen compound | male mating behavior | regulation of epithelial to mesenchymal transition | cellular response to electrical stimulus | negative regulation of keratinocyte migration | response to electrical stimulus | negative regulation of synaptic transmission | positive regulation of ubiquitin-protein transferase activity | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of synaptic plasticity | positive regulation of neuron differentiation | phospholipid dephosphorylation | locomotor rhythm | regulation of cell projection organization | cellular metabolic process | long-term synaptic potentiation | negative regulation of cell cycle process | ameboidal-type cell migration | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | negative regulation of cell death | negative regulation of cell development | circulatory system development | postsynaptic density organization | negative regulation of myelination | regulation of ubiquitin-dependent protein catabolic process | negative regulation of locomotion | sexual reproduction | positive regulation of protein ubiquitination | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | positive regulation of signaling | inositol phosphate metabolic process | signal transduction | cellular response to leptin stimulus | regulation of signaling | positive regulation of gene expression | regulation of cell-matrix adhesion | regulation of muscle organ development | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendritic spine | cytoplasmic side of plasma membrane | myelin sheath adaxonal region | dendrite | intracellular membrane-bounded organelle | synapse | apical plasma membrane | neuron projection | somatodendritic compartment | cell | cytoplasmic side of membrane | nuclear lumen | synaptic membrane | compact myelin | cytoplasm | intracellular organelle | dendritic tree | apical part of cell | cell projection | postsynaptic membrane | neuron spine | postsynapse | nucleoplasm | plasma membrane | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | Schmidt-Lanterman incisure | cytosol | intracellular | myelin sheath | membrane
