QuickView for PTK2;jsessionid=FAD184C50C877DF2E6A2E5494D3F53CE;jsessionid=08B6DEDA3938D5F4727326DE16ACCA18;jsessionid=4E2567B40AAD802527A9542AC901F0BF (gene)
- Gene Symbol:
- Ptk2
Mus musculus - Full name:
- PTK2 protein tyrosine kinase 2
- Synonyms:
- FADK 1, FAK, FRNK, Fadk, p125FAK, focal adhesion kinase 1, focal adhesion kinase-related nonkinase, focal ashension kinase 1, pp125FAK, protein-tyrosine kinase 2
- Genomic Location:
- Chr 15: 73035536-73225154
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AP4_01 , AACTTT_UNKNOWN , ETS1_B , CTGCAGY_UNKNOWN , CEBPGAMMA_Q6 , TEL2_Q6 , ICSBP_Q6 , ETS_Q4 , IRF_Q6 , AAGCCAT_MIR135A_MIR135B
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
actin binding | phosphatidylinositol 3-kinase binding | kinase binding | protein kinase binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | JUN kinase binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | catalytic activity | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding | SH2 domain binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | regulation of blood vessel diameter | cell morphogenesis | regulation of muscle system process | positive regulation of locomotion | extracellular structure organization | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | intracellular signal transduction | regulation of synapse assembly | regulation of cell development | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | establishment of localization | regulation of autophagy | response to hormone | regulation of cell shape | neuron migration | negative regulation of cellular process | integrin-mediated signaling pathway | positive regulation of developmental process | microtubule cytoskeleton organization | cell differentiation | signal complex assembly | negative regulation of organ growth | nervous system development | response to growth hormone | positive regulation of protein catabolic process | epithelial cell migration | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular component movement | generation of neurons | intracellular transport | microtubule-based process | blood vessel morphogenesis | cellular process | negative regulation of axonogenesis | establishment of organelle localization | regulation of cell motility | central nervous system neuron axonogenesis | localization | cellular homeostasis | cell projection morphogenesis | positive regulation of synaptic transmission | negative regulation of synapse organization | neuron development | negative regulation of developmental growth | central nervous system neuron differentiation | negative regulation of anoikis | anion homeostasis | epithelium migration | positive regulation of protein kinase activity | negative regulation of apoptotic process | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | regulation of neuron projection development | cellular response to growth hormone stimulus | establishment of localization in cell | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | negative regulation of cell motility | regulation of protein kinase B signaling | peptidyl-tyrosine autophosphorylation | regulation of cellular process | positive regulation of cell growth | regulation of osteoblast differentiation | regulation of apoptotic process | regulation of metabolic process | organelle localization | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | ephrin receptor signaling pathway | cellular component organization | negative regulation of cell morphogenesis involved in differentiation | MAPK cascade | response to transforming growth factor beta | positive regulation of cellular protein catabolic process | response to stimulus | vasculature development | cell morphogenesis involved in neuron differentiation | JNK cascade | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | regulation of cellular protein catabolic process | negative regulation of cell adhesion | regulation of blood vessel size | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | endothelial cell migration | regulation of cell proliferation | negative regulation of neuron projection development | tube morphogenesis | response to peptide | regulation of smooth muscle cell migration | positive regulation of proteolysis involved in cellular protein catabolic process | cellular localization | cellular monovalent inorganic anion homeostasis | cardiovascular system development | positive regulation of proteolysis | extracellular matrix organization | positive regulation of gliogenesis | ERBB signaling pathway | regulation of phagocytosis | blood circulation | negative regulation of metabolic process | cellular component assembly | regulation of anoikis | protein modification process | regulation of synapse structure or activity | modulation of chemical synaptic transmission | regulation of cell adhesion | macromolecule modification | blood vessel development | stress-activated protein kinase signaling cascade | locomotion | response to nitrogen compound | central nervous system neuron development | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | regulation of adherens junction organization | multicellular organism development | cell migration | cellular response to peptide hormone stimulus | phosphorus metabolic process | positive regulation of smooth muscle cell migration | regulation of axonogenesis | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | regulation of ossification | regulation of neuron differentiation | axon development | cellular response to stress | cellular response to peptide | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | regulation of synapse organization | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | axonogenesis | positive regulation of cell differentiation | positive regulation of cell migration | stress-activated MAPK cascade | regulation of cellular protein metabolic process | angiogenesis | regulation of cell adhesion mediated by integrin | phosphorylation | cellular protein-containing complex assembly | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | negative regulation of autophagy | nuclear migration | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of glial cell proliferation | regulation of protein metabolic process | positive regulation of signal transduction | vasculogenesis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of tube size | positive regulation of transport | protein tyrosine kinase activity | positive regulation of glial cell proliferation | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | nucleus localization | neuron differentiation | cellular chloride ion homeostasis | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | protein metabolic process | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | regulation of growth | response to organic substance | negative regulation of cell projection organization | regulation of kinase activity | regulation of intracellular signal transduction | regulation of focal adhesion assembly | anatomical structure development | chloride ion homeostasis | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | regulation of tube diameter | regulation of vesicle-mediated transport | chemical homeostasis | protein kinase activity | neuron projection development | organic substance metabolic process | negative regulation of neuron differentiation | negative regulation of cellular component movement | positive regulation of kinase activity | positive regulation of phagocytosis | ion homeostasis | regulation of phosphate metabolic process | cytoskeleton organization | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | regulation of gliogenesis | signaling | positive regulation of growth | cell development | regulation of endocytosis | regulation of developmental growth | growth hormone receptor signaling pathway | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | regulation of organ growth | regulation of nervous system development | regulation of developmental process | kinase activity | developmental process | organelle organization | regulation of cell growth | cellular protein modification process | tube development | regulation of cell junction assembly | regulation of transport | regulation of cell-cell adhesion | response to organonitrogen compound | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of cell projection organization | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | regulation of substrate adhesion-dependent cell spreading | negative regulation of cell death | negative regulation of cell development | positive regulation of blood vessel diameter | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | negative regulation of synapse assembly | negative regulation of locomotion | positive regulation of endocytosis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendritic spine | intercalated disc | dendrite | intracellular membrane-bounded organelle | sarcolemma | synapse | apical plasma membrane | neuron projection | somatodendritic compartment | adherens junction | focal adhesion | cell | nuclear lumen | nucleolus | lamellipodium | cytoplasm | cell-substrate junction | intracellular organelle | actin cytoskeleton | nuclear body | dendritic tree | apical part of cell | cell-cell junction | cell-cell contact zone | cell projection | neuron spine | postsynapse | nucleoplasm | plasma membrane | actomyosin | cell leading edge | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | basolateral plasma membrane | cell-substrate adherens junction | stress fiber | cytosol | cytoskeleton | intracellular | cell junction | actin filament bundle | membrane
