QuickView for Pabp;jsessionid=04F8F44821C2C5A2D25CC927299A78C6;jsessionid=822F9237BD26247E1827D33835C29DA5;jsessionid=97BB94789E1258178E69D775168DC942;jsessionid=D2C66890EA3A21EE68D271C71860FB2A (gene)

Gene Symbol:

PABPC4 Homo sapiens

Full name:

poly(A) binding protein cytoplasmic 4

Synonyms:

APP-1, APP1, PABP4, iPABP, polyadenylate-binding protein 4, PABP-4, activated-platelet protein 1, inducible poly(A)-binding protein, poly(A) binding protein, cytoplasmic 4 (inducible form), poly(A)-binding protein 4

Genomic Location:

Chr 1: 39799075-39815003

Description:

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-r...

View Full Description

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  MYC_Q2 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  ZF5_01 ,  AP2GAMMA_01 ,  AMEF2_Q6 ,  AP2ALPHA_01 ,  EGR2_01 ,  TAAWWATAG_RSRFC4_Q2 ,  TATAAA_TATA_01 ,  MYCMAX_02 ,  CAGGTG_E12_Q6 ,  GR_Q6 ,  AP2_Q6_01 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  NMYC_01 ,  SCGGAAGY_ELK1_02 ,  IRF7_01 ,  TATA_01 ,  E2F_Q2 ,  TCCATTKW_UNKNOWN ,  USF2_Q6 ,  TCF1P_Q6 ,  PAX4_01 ,  SF1_Q6 ,  MEF2_Q6_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-192

Cytogenetic Map:

1p34.3

search → result