QuickView for Pep5;jsessionid=97A1DED6882FB03061F6659DCA2E09B6;jsessionid=A6154639D95435FBBC19592494E04701;jsessionid=A7FFFE9A559B8C04377E4DFDA7CCDC10;jsessionid=EB3E7997737DBBAB397BFDE10FB4EF0A (gene)

Gene Symbol:

VPS11 Homo sapiens

Full name:

VPS11, CORVET/HOPS core subunit

Synonyms:

END1, HLD12, PEP5, RNF108, hVPS11, vacuolar protein sorting-associated protein 11 homolog, RING finger protein 108, vacuolar protein sorting 11 homolog

Genomic Location:

Chr 11: 118443703-118457898

Description:

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C V...

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Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TCANNTGAY_SREBP1_01 ,  PEA3_Q6 ,  ELK1_01 ,  GATA4_Q3

Cytogenetic Map:

11q23.3

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