QuickView for RAB5A;jsessionid=4FCDAD71E10E9874EA13FC17D3B67133;jsessionid=1A2013891E514088E1338236BBE7EA13;jsessionid=D710A564029315F1D05ED102AE506555 (gene)
- Gene Symbol:
- VPS21
Saccharomyces cerevisiae - Full name:
- GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
- Synonyms:
- VPS12, VPS21, VPT12, YOR089C, YPT21, YPT51
- Genomic Location:
- Chr XV: 490198-490830
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
guanyl ribonucleotide binding | ribonucleoside binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
intracellular signal transduction | protein localization to vacuole | macroautophagy | establishment of localization | selective autophagy | intracellular transport | protein localization to endosome | cellular process | endosome transport via multivesicular body sorting pathway | localization | protein transport | vacuole inheritance | macromolecule localization | endomembrane system organization | establishment of localization in cell | cytosolic transport | regulation of cellular process | catabolic process | small GTPase mediated signal transduction | cellular component organization | Golgi to endosome transport | response to stimulus | endosomal transport | intracellular protein transport | vacuolar transport | cellular localization | cellular component assembly | protein targeting to vacuole | organelle assembly | post-Golgi vesicle-mediated transport | organic substance transport | multivesicular body assembly | peptide transport | vesicle-mediated transport | protein localization to organelle | vacuole organization | autophagy | cell communication | Golgi vesicle transport | organelle disassembly | late endosome to vacuole transport via multivesicular body sorting pathway | import into cell | establishment of protein localization to organelle | metabolic process | Rab protein signal transduction | cellular protein localization | amide transport | endocytosis | multivesicular body organization | establishment of protein localization to vacuole | late endosome to vacuole transport | establishment of protein localization | vesicle organization | signaling | protein localization | cellular macromolecule localization | endosome organization | organelle inheritance | organelle organization | Ras protein signal transduction | reticulophagy | protein targeting | cellular metabolic process | multivesicular body sorting pathway | signal transduction
GO Cellular Component
intracellular membrane-bounded organelle | late endosome | organelle membrane | cytoplasmic vesicle | cell | organelle outer membrane | cytoplasm | intracellular organelle | endosome membrane | endomembrane system | plasma membrane | vesicle | mitochondrion | endosome | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | cell periphery | early endosome | outer membrane | mitochondrial membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane
