QuickView for RII;jsessionid=A1ABB5ECF1370E7605287ACD51351C30;jsessionid=82B8A369B37583E2F91F337D0988C30E (gene)

Gene Symbol:

PRKAR2A Homo sapiens

Full name:

protein kinase cAMP-dependent type II regulatory subunit alpha

Synonyms:

PKR2, PRKAR2, cAMP-dependent protein kinase type II-alpha regulatory subunit, cAMP-dependent protein kinase regulatory subunit RII alpha, protein kinase A, RII-alpha subunit, protein kinase, cAMP-dependent, regulatory subunit type II alpha

Genomic Location:

Chr 3: 48763097-48860274

Description:

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dis...

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cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGNNNNNNKCCAR_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  LHX3_01 ,  CAGGGTC_MIR504 ,  BACH2_01 ,  NF1_Q6 ,  HIF1_Q5 ,  AHR_Q5 ,  TCTCTCC_MIR185 ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  YTAATTAA_LHX3_01 ,  RCGCANGCGY_NRF1_Q6 ,  ZF5_B ,  HIF1_Q3 ,  CACTTTG_MIR520G_MIR520H ,  AAGTCCA_MIR422B_MIR422A

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-503

Cytogenetic Map:

3p21.31

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