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QuickView for RP58;jsessionid=EF4BE670A1E5B3956AB7E3C4F797D387;jsessionid=E0E98E8FEA6B609195D60E2DA9C08AAC (gene)


Gene Symbol:
ZBTB18 Homo sapiens Homo sapiens
Full name:
zinc finger and BTB domain containing 18
Synonyms:
C2H2-171, MRD22, RP58, TAZ-1, ZNF238, zinc finger and BTB domain-containing protein 18, 58 kDa repressor protein, transcriptional repressor RP58, translin-associated zinc finger protein 1, zinc finger protein 238, zinc finger protein C2H2-171
Genomic Location:
Chr 1: 242281184-242287401
Description:
This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 FOXO1_02 POU6F1_01 PBX1_02 RTAAACA_FREAC2_01 PAX4_04 OCT1_05 FREAC7_01 TTTGCAC_MIR19A_MIR19B SMTTTTGT_UNKNOWN
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-101 Predicted Gene Targets for miR-130 Predicted Gene Targets for miR-132 Predicted Gene Targets for miR-142-5p Predicted Gene Targets for miR-144 Predicted Gene Targets for miR-148 Predicted Gene Targets for miR-19 Predicted Gene Targets for miR-199 Predicted Gene Targets for miR-20 Predicted Gene Targets for miR-141
Cytogenetic Map:
chr 1
1q44





GO Molecular Function

sequence-specific DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | DNA-binding transcription factor activity | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | positive regulation of macromolecule biosynthetic process | muscle tissue development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | muscle structure development | skeletal muscle organ development | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | response to stress | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | cellular response to DNA damage stimulus | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | striated muscle tissue development | regulation of cellular metabolic process | transcription coactivator activity | regulation of RNA metabolic process | DNA-binding transcription factor activity | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | muscle organ development | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular