QuickView for RhoGTPase;jsessionid=F27EE3340B00119D707AC81EB99515F0;jsessionid=3F5B9F210D1B4DD27A77ADBF93B91DA5 (gene)

Gene Symbol:

RHOBTB2 Homo sapiens

Full name:

Rho related BTB domain containing 2

Synonyms:

DBC2, rho-related BTB domain-containing protein 2, deleted in breast cancer 2 gene protein, p83

Genomic Location:

Chr 8: 22913407-22933653

Description:

The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found...

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The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGGAARNGGCNG_UNKNOWN ,  CEBPA_01 ,  OCT1_B ,  OCT1_04 ,  P53_DECAMER_Q2 ,  OCT1_01 ,  E4BP4_01 ,  WGTTNNNNNAAA_UNKNOWN ,  CYTAGCAAY_UNKNOWN ,  TTAYRTAA_E4BP4_01 ,  GATA1_04 ,  GGGAGGRR_MAZ_Q6 ,  CEBP_Q2 ,  P53_02 ,  RFX1_02 ,  TGCTGAY_UNKNOWN ,  CREBP1_01 ,  GTTGNYNNRGNAAC_UNKNOWN ,  CTTTAAR_UNKNOWN ,  HLF_01 ,  CTGCAGY_UNKNOWN ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  PAX4_03 ,  CTGRYYYNATT_UNKNOWN ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

8p21.3

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