QuickView for Rhp18;jsessionid=E7906F056A07038EE1B4CA014700BD0B;jsessionid=7937BC16A95587EA802B6ACF5FE2C6E3 (gene)
- Gene Symbol:
- RAD18
Homo sapiens - Full name:
- RAD18, E3 ubiquitin protein ligase
- Synonyms:
- RNF73, E3 ubiquitin-protein ligase RAD18, RAD18 homolog, RAD18, S. cerevisiae, homolog, RING finger protein 73, RING-type E3 ubiquitin transferase RAD18, hHR18, hRAD18, postreplication repair protein RAD18, postreplication repair protein hRAD18p
- Genomic Location:
- Chr 3: 8896560-8980146
- Description:
-
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast...
- Orthologs:
- Mus musculus , Rattus norvegicus , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3p25.3
GO Molecular Function
single-stranded DNA-dependent ATPase activity | cation binding | DNA secondary structure binding | enzyme binding | nucleic acid binding | protein-containing complex binding | hydrolase activity | Y-form DNA binding | ATPase activity | pyrophosphatase activity | catalytic activity | polyubiquitin modification-dependent protein binding | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | modification-dependent protein binding | nucleoside-triphosphatase activity | ATPase activity, coupled | DNA binding | identical protein binding | ubiquitin protein ligase activity | damaged DNA binding | ion binding | organic cyclic compound binding | protein binding | ubiquitin protein ligase binding | ubiquitin-protein transferase activity | hydrolase activity, acting on acid anhydrides | transferase activity | ubiquitin-like protein ligase activity | DNA-dependent ATPase activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO Biological Process
response to radiation | detection of stimulus | negative regulation of cellular process | regulation of chromosome segregation | cellular process | postreplication repair | regulation of cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to UV | response to stimulus | response to stress | cellular nitrogen compound metabolic process | protein modification process | macromolecule modification | DNA repair | response to light stimulus | nitrogen compound metabolic process | protein monoubiquitination | cellular response to DNA damage stimulus | cellular response to stress | protein modification by small protein conjugation | ubiquitin protein ligase activity | protein metabolic process | protein ubiquitination | DNA metabolic process | protein autoubiquitination | DNA damage response, detection of DNA damage | metabolic process | ubiquitin-protein transferase activity | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of chromosome segregation | protein modification by small protein conjugation or removal | cellular protein metabolic process | cellular protein modification process | heterocycle metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | macromolecule metabolic process
GO Cellular Component
nuclear inclusion body | site of DNA damage | chromosome | intracellular membrane-bounded organelle | catalytic complex | microtubule organizing center | cell | nuclear lumen | replication fork | cytoplasm | intracellular organelle | ubiquitin ligase complex | nuclear body | inclusion body | centrosome | protein-containing complex | nucleoplasm | transferase complex | microtubule cytoskeleton | site of double-strand break | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | Rad6-Rad18 complex | intracellular
