QuickView for Rna14;jsessionid=BA0A2137E6DC692793060CF06880D0E0;jsessionid=F84C5BFE6873490FF2DE8E2E8A22EAFA (gene)

Gene Symbol:

CSTF3 Homo sapiens

Full name:

cleavage stimulation factor subunit 3

Synonyms:

CSTF-77, cleavage stimulation factor subunit 3, CF-1 77 kDa subunit, CSTF 77 kDa subunit, cleavage stimulation factor 77 kDa subunit, cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kD, cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa

Genomic Location:

Chr 11: 33062706-33139613

Description:

The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2...

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The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  IRF1_01 ,  CTCTATG_MIR368 ,  CREBP1CJUN_01 ,  ATTACAT_MIR3803P ,  TTTGTAG_MIR520D ,  AACTGGA_MIR145 ,  EGR2_01 ,  CREB_Q4 ,  GGGNRMNNYCAT_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  TST1_01 ,  WYAAANNRNNNGCG_UNKNOWN ,  TGCCTTA_MIR124A ,  GTTTGTT_MIR495 ,  GGGCGGR_SP1_Q6 ,  E4F1_Q6 ,  RNGTGGGC_UNKNOWN ,  AAAYRNCTG_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  CREB_Q2 ,  ACACTAC_MIR1423P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

11p13

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