QuickView for S6K;jsessionid=141179AEA469E869D9D82AC3CBCAF323;jsessionid=0FA467D89DBFB1E4D333B705A618C7A8 (gene)

Gene Symbol:

RPS6KB1 Homo sapiens

Full name:

ribosomal protein S6 kinase B1

Synonyms:

PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha, ribosomal protein S6 kinase beta-1, p70 S6 kinase, alpha, ribosomal protein S6 kinase I, ribosomal protein S6 kinase, 70kDa, polypeptide 1, serine/threonine kinase 14 alpha, serine/threonine-protein kinase 14A

Genomic Location:

Chr 17: 55325225-55382569

Description:

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been o...

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This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACAACCT_MIR453 ,  CTTGTAT_MIR381 ,  CACTGTG_MIR128A_MIR128B ,  GTATTAT_MIR3693P ,  TGIF_01 ,  GATA1_01 ,  AAGCCAT_MIR135A_MIR135B ,  GNCF_01 ,  FOX_Q2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HFH3_01 ,  AP3_Q6 ,  AAAYWAACM_HFH4_01 ,  AACTGAC_MIR223 ,  FOXD3_01 ,  CTTTGCA_MIR527 ,  HFH1_01 ,  CTATGCA_MIR153 ,  TGTGTGA_MIR377 ,  EVI1_04 ,  TTTGTAG_MIR520D ,  GTGCAAA_MIR507 ,  ACTGTGA_MIR27A_MIR27B ,  WTGAAAT_UNKNOWN ,  GTGTGAG_MIR342 ,  TGCAAAC_MIR452 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  TGCGCANK_UNKNOWN ,  GTCTTCC_MIR7 ,  TGCCTTA_MIR124A ,  ATTCTTT_MIR186 ,  GCAAAAA_MIR129 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  ACTGCCT_MIR34B ,  OCT1_03 ,  AAAGACA_MIR511 ,  HFH4_01 ,  MEIS1_01 ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  AREB6_03 ,  GFI1_01 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  YTAAYNGCT_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IRF7_01 ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  PAX2_02 ,  AAGCACA_MIR218 ,  LMO2COM_01 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

17q23.1

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