QuickView for SACM1L;jsessionid=5D0F1B011BE9DAFFB2A71FC499713F4B;jsessionid=25897A6C59FF448341329DB2330B8098 (gene)

Gene Symbol:

Sacm1l Mus musculus

Full name:

SAC1 suppressor of actin mutations 1-like (yeast)

Synonyms:

SAC1, Sac1p, mKIAA0851, phosphatidylinositide phosphatase SAC1, polyphosphatidylinositol phosphatase, suppressor of actin mutations 1-like protein

Genomic Location:

Chr 9: 123439000-123501716

Description:

This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other stu...

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This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CHX10_01 ,  E4F1_Q6 ,  GCGCCTT_MIR525_MIR524 ,  AACTGGA_MIR145 ,  CTTTGA_LEF1_Q2 ,  TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-544

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