QuickView for SERPINE1;jsessionid=E99CE55BEE13BF8EBACC9AA6FECC23F5;jsessionid=52AD71536039B966FEBBF666F510F71D;jsessionid=12ED602ADC86FDE538364295A17D268E;jsessionid=3CB6C2825344E889C4302AA5C4B6A589 (gene)
- Gene Symbol:
- Serpine1
Mus musculus - Full name:
- serine (or cysteine) peptidase inhibitor, clade E, member 1
- Synonyms:
- PAI-1, PAI1, Planh1, plasminogen activator inhibitor 1, PAI, Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI), endothelial plasminogen activator inhibitor, nexin, plasminogen activator inhibitor type 1, plasminogen activator inhibitor, type I, serine (or cysteine) proteinase inhibitor, clade E, member 1, serpin E1
- Genomic Location:
- Chr 5: 137537378-137548129
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
endopeptidase inhibitor activity | enzyme binding | enzyme inhibitor activity | signaling receptor binding | molecular function regulator | protein binding | serine-type endopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | protease binding
GO Biological Process
regulation of leukocyte chemotaxis | regulation of odontoblast differentiation | positive regulation of locomotion | endopeptidase inhibitor activity | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | response to lipopolysaccharide | developmental process involved in reproduction | regulation of localization | positive regulation of collagen metabolic process | gonad development | regulation of programmed cell death | female gonad development | defense response to other organism | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | positive regulation of fibroblast proliferation | defense response | negative regulation of cell-matrix adhesion | response to drug | positive regulation of cellular component movement | defense response to Gram-negative bacterium | negative regulation of proteolysis | cellular process | positive regulation of keratinocyte migration | regulation of cell motility | odontogenesis | negative regulation of smooth muscle cell migration | negative regulation of signaling | positive regulation of blood coagulation | reproductive system development | regulation of chemotaxis | negative regulation of apoptotic process | negative regulation of smooth muscle cell-matrix adhesion | regulation of proteolysis | regulation of monocyte chemotaxis | response to growth factor | negative regulation of cell migration | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of apoptotic signaling pathway | negative regulation of vascular wound healing | negative regulation of cell motility | negative regulation of wound healing | regulation of angiogenesis | positive regulation of interleukin-8 production | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | response to transforming growth factor beta | positive regulation of epithelial cell migration | development of primary sexual characteristics | regulation of vasculature development | response to stimulus | enzyme inhibitor activity | negative regulation of epithelial cell apoptotic process | positive regulation of immune system process | regulation of plasminogen activation | negative regulation of cell adhesion | response to stress | regulation of cell proliferation | negative regulation of angiogenesis | regulation of epithelial cell differentiation | regulation of smooth muscle cell migration | development of primary female sexual characteristics | reproduction | response to molecule of bacterial origin | negative regulation of metabolic process | regulation of wound healing | regulation of protein processing | regulation of cell adhesion | molecular function regulator | response to external biotic stimulus | system development | positive regulation of response to wounding | reproductive process | regulation of signal transduction | positive regulation of monocyte chemotaxis | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of collagen biosynthetic process | positive regulation of inflammatory response | regulation of catalytic activity | negative regulation of peptidase activity | wound healing | positive regulation of calcium ion import | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | regulation of gene expression | positive regulation of chemotaxis | regulation of extrinsic apoptotic signaling pathway | positive regulation of leukotriene production involved in inflammatory response | response to lipid | animal organ morphogenesis | regulation of blood coagulation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | regulation of cellular component movement | regulation of endothelial cell apoptotic process | dentinogenesis | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | positive regulation of cell migration | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | negative regulation of cell-substrate adhesion | regulation of cell adhesion mediated by integrin | regulation of apoptotic signaling pathway | regulation of smooth muscle cell-matrix adhesion | regulation of epithelial cell apoptotic process | regulation of leukocyte migration | cellular response to drug | negative regulation of response to wounding | response to bacterium | regulation of cellular metabolic process | positive regulation of leukocyte chemotaxis | odontogenesis of dentin-containing tooth | negative regulation of protein processing | regulation of collagen metabolic process | regulation of protein metabolic process | defense response to bacterium | positive regulation of cell proliferation | regulation of locomotion | positive regulation of transport | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | cell aging | negative regulation of plasminogen activation | cellular response to transforming growth factor beta stimulus | regulation of signaling receptor activity | regulation of fibroblast proliferation | response to organic substance | response to wounding | positive regulation of odontoblast differentiation | replicative senescence | positive regulation of mononuclear cell migration | anatomical structure development | regulation of body fluid levels | negative regulation of programmed cell death | positive regulation of coagulation | regulation of vesicle-mediated transport | negative regulation of gene expression | animal organ development | positive regulation of ion transport | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | positive regulation of leukocyte migration | positive regulation of wound healing | positive regulation of cytokine production | serine-type endopeptidase inhibitor activity | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of epithelial cell migration | regulation of calcium ion import | regulation of response to wounding | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | regulation of endocytosis | regulation of fibrinolysis | peptidase inhibitor activity | enzyme regulator activity | regulation of cytokine production | anatomical structure morphogenesis | regulation of endopeptidase activity | response to biotic stimulus | reproductive structure development | regulation of developmental process | regulation of ion transport | developmental process | cellular response to interleukin-1 | regulation of calcium ion transport | positive regulation of epithelial cell differentiation | regulation of transport | negative regulation of cell adhesion mediated by integrin | negative regulation of vasculature development | regulation of vascular wound healing | negative regulation of hydrolase activity | positive regulation of metabolic process | positive regulation of collagen biosynthetic process | placenta development | negative regulation of fibrinolysis | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | positive regulation of cell motility | negative regulation of cell death | regulation of inflammatory response | aging | negative regulation of locomotion | positive regulation of endocytosis | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of calcium ion transport | response to other organism | regulation of signaling | negative regulation of endopeptidase activity | negative regulation of endothelial cell apoptotic process | positive regulation of gene expression | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | multicellular organismal process
GO Cellular Component
secretory granule | chromaffin granule | extracellular matrix | cytoplasmic vesicle | cell | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | secretory vesicle | endomembrane system | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | intracellular vesicle | intracellular
