QuickView for SGK-1;jsessionid=F53A3B3E54E9317A220D539A68200A67;jsessionid=42100F445920973E84BBD3CD31488BBC (gene)

Gene Symbol:

SGK1 Homo sapiens

Full name:

serum/glucocorticoid regulated kinase 1

Synonyms:

SGK, serine/threonine-protein kinase Sgk1, Sgk1 variant i3, serine/threonine protein kinase SGK

Genomic Location:

Chr 6: 134532081-134537695

Description:

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gen...

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This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ACAACTT_MIR382 ,  TTTGCAC_MIR19A_MIR19B ,  HNF3ALPHA_Q6 ,  STAT4_01 ,  TGANTCA_AP1_C ,  DR3_Q4 ,  RYTTCCTG_ETS2_B ,  HFH3_01 ,  ATGTCAC_MIR489 ,  CACGTG_MYC_Q2 ,  STAT6_02 ,  AAAYWAACM_HFH4_01 ,  FOXD3_01 ,  LXR_DR4_Q3 ,  ATF4_Q2 ,  STAT6_01 ,  ARNT_02 ,  GTAAACC_MIR2995P ,  FAC1_01 ,  IRF1_Q6 ,  GGGCATT_MIR365 ,  HNF4_DR1_Q3 ,  OSF2_Q6 ,  AP1_Q6_01 ,  ATF_01 ,  AR_01 ,  HNF3_Q6 ,  BACH2_01 ,  GTAAGAT_MIR200A ,  GTTTGTT_MIR495 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  HFH4_01 ,  TGTTTGY_HNF3_Q6 ,  AHRARNT_01 ,  GTGCCTT_MIR506 ,  AATGTGA_MIR23A_MIR23B ,  BACH1_01 ,  USF_Q6_01 ,  TTGTTT_FOXO4_01 ,  SRF_Q5_01 ,  LXR_Q3 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  DR4_Q2 ,  HTF_01 ,  ACACTAC_MIR1423P ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-495

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Cytogenetic Map:

6q23.2

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