QuickView for SIN3A;jsessionid=7E2F3F547E520AA5324A79A9E7005B90;jsessionid=7CB57E8121783FF06E3A776515D12139;jsessionid=51D023A7A50A870702A6D9473E5A47EF (gene)
- Gene Symbol:
- SIN3
Saccharomyces cerevisiae - Full name:
- Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
- Synonyms:
- CPE1, GAM2, RPD1, SDI1, SDS16, SIN3, SIN3, Sin3, UME4, YOL004W
- Genomic Location:
- Chr XV: 316939-321549
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AP4_01 , NFKAPPAB65_01 , CREL_01 , NFKAPPAB_01 , HEN1_01 , HNF3B_01 , SRF_Q6 , NFKB_Q6 , NFKB_C , NGFIC_01
GO Molecular Function
hydrolase activity | protein deacetylase activity | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | histone deacetylase activity | transcription corepressor activity | transcription coactivator activity | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | transcription coregulator activity
GO Biological Process
RNA metabolic process | double-strand break repair | positive regulation of macromolecule biosynthetic process | regulation of chromatin silencing at telomere | regulation of transcription by RNA polymerase I | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | negative regulation of chromatin silencing at silent mating-type cassette | histone deacetylation | regulation of DNA replication | regulation of organelle organization | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | reproduction | response to temperature stimulus | regulation of gene silencing | cellular nitrogen compound metabolic process | double-strand break repair via nonhomologous end joining | positive regulation of transcription from RNA polymerase II promoter in response to heat stress | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | protein deacetylase activity | cellular biosynthetic process | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | reproductive process | cellular response to DNA damage stimulus | regulation of gene expression | histone deacetylase activity | cellular response to stress | cell cycle | cellular response to heat | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of DNA-dependent DNA replication initiation | transcription corepressor activity | negative regulation of chromatin silencing at rDNA | regulation of transcription by RNA polymerase II | positive regulation of gene expression, epigenetic | biosynthetic process | cell division | protein deacetylation | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | G2/M transition of mitotic cell cycle | regulation of DNA-dependent DNA replication | mitotic cell cycle phase transition | negative regulation of transcription by RNA polymerase I | regulation of cellular metabolic process | cell cycle G2/M phase transition | transcription coactivator activity | regulation of RNA metabolic process | regulation of chromatin silencing at silent mating-type cassette | negative regulation of gene silencing | protein metabolic process | regulation of transcription involved in G2/M transition of mitotic cell cycle | DNA metabolic process | mitotic cell cycle | metabolic process | negative regulation of chromatin silencing | regulation of DNA-templated transcription in response to stress | regulation of chromatin silencing | negative regulation of transcription involved in meiotic cell cycle | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | transfer RNA gene-mediated silencing | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | response to heat | regulation of chromosome organization | regulation of chromatin silencing at rDNA | transcription, DNA-templated | meiotic cell cycle | negative regulation of chromatin silencing at telomere | negative regulation of chromosome organization | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | cellular macromolecule biosynthetic process | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | chromatin silencing | cellular metabolic process | regulation of transcription involved in meiotic cell cycle | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | regulation of chromatin organization
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | catalytic complex | Rpd3L-Expanded complex | Rpd3L complex | cell | nuclear lumen | intracellular organelle | protein-containing complex | histone deacetylase complex | nucleoplasm | chromatin | nuclear chromosome | Rpd3S complex | membrane-bounded organelle | nucleus | Sin3-type complex | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular
