QuickView for SORL1;jsessionid=254D02B343E6EF13479E09D99C1759B1;jsessionid=F22C56D8CB9283008535C86DC1F47641;jsessionid=AB0C143C529E5EEDF8BC0100922BA186 (gene)
- Gene Symbol:
- Sorl1
Rattus norvegicus - Full name:
- sortilin related receptor 1
- Synonyms:
- Lr11, RGD619914, sortilin-related receptor, sortilin-related receptor, LDLR class A repeats-containing
- Genomic Location:
- Chr 8: 44962560-45206124
- Description:
-
may play a role in lipoprotein metabolism; increased expression occurs in response to balloon injury endothelial denudation in an experimental model for atherogenesis
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
| Protein Names |
|---|
| No proteins found. |
GO Molecular Function
GTPase binding | peptide binding | amyloid-beta binding | enzyme binding | protein-containing complex binding | lipoprotein particle binding | amide binding | ADP-ribosylation factor binding | low-density lipoprotein particle binding | protein binding | small GTPase binding
GO Biological Process
negative regulation of amyloid-beta formation | negative regulation of metalloendopeptidase activity | negative regulation of phosphorylation | regulation of intracellular protein transport | negative regulation of MAPK cascade | cell motility | positive regulation of protein localization to early endosome | regulation of neurogenesis | regulation of cellular localization | regulation of cell development | protein localization to vacuole | regulation of localization | establishment of localization | regulation of endocytic recycling | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | cell differentiation | nervous system development | positive regulation of protein catabolic process | negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process | negative regulation of protein phosphorylation | neurogenesis | regulation of protein oligomerization | negative regulation of neurofibrillary tangle assembly | generation of neurons | intracellular transport | positive regulation of protein localization to endosome | negative regulation of proteolysis | regulation of neuron death | cellular process | regulation of cell motility | localization | regulation of early endosome to recycling endosome transport | negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | protein transport | negative regulation of signaling | macromolecule localization | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of early endosome to recycling endosome transport | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | regulation of protein complex assembly | lysosomal transport | regulation of cellular protein localization | protein targeting to lysosome | positive regulation of protein metabolic process | intracellular protein transport | negative regulation of protein kinase activity | positive regulation of cellular protein localization | vacuolar transport | regulation of smooth muscle cell migration | protein retention in Golgi apparatus | cellular localization | negative regulation of aspartic-type peptidase activity | negative regulation of protein oligomerization | regulation of protein exit from endoplasmic reticulum | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | negative regulation of amyloid precursor protein catabolic process | regulation of intracellular transport | protein targeting to vacuole | locomotion | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of peptidase activity | regulation of MAPK cascade | regulation of tau-protein kinase activity | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | protein localization to lysosome | negative regulation of peptidase activity | post-Golgi vesicle-mediated transport | organic substance transport | positive regulation of intracellular protein transport | negative regulation of metallopeptidase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | peptide transport | negative regulation of protein serine/threonine kinase activity | vesicle-mediated transport | regulation of cellular component movement | protein localization to organelle | negative regulation of binding | cell proliferation | regulation of cellular protein metabolic process | protein maturation | regulation of amyloid precursor protein catabolic process | maintenance of protein location | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of ER to Golgi vesicle-mediated transport | regulation of protein metabolic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | Golgi vesicle transport | negative regulation of MAP kinase activity | positive regulation of transport | positive regulation of molecular function | protein localization to Golgi apparatus | protein metabolic process | regulation of establishment of protein localization | positive regulation of endocytic recycling | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | establishment of protein localization to organelle | anatomical structure development | positive regulation of choline O-acetyltransferase activity | negative regulation of tau-protein kinase activity | metabolic process | regulation of protein catabolic process | cellular protein localization | amide transport | regulation of vesicle-mediated transport | negative regulation of protein complex assembly | organic substance metabolic process | negative regulation of cellular protein metabolic process | gene expression | maintenance of protein location in cell | regulation of phosphate metabolic process | establishment of protein localization to vacuole | negative regulation of inclusion body assembly | establishment of protein localization | positive regulation of intracellular transport | positive regulation of protein transport | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of protein binding | regulation of amyloid-beta formation | protein localization | regulation of endopeptidase activity | cellular macromolecule localization | regulation of nervous system development | regulation of developmental process | developmental process | regulation of inclusion body assembly | regulation of transport | positive regulation of ER to Golgi vesicle-mediated transport | negative regulation of hydrolase activity | positive regulation of protein exit from endoplasmic reticulum | positive regulation of metabolic process | protein targeting | regulation of protein localization | regulation of cell death | negative regulation of cell death | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | regulation of signaling | negative regulation of endopeptidase activity | macromolecule metabolic process | negative regulation of neurogenesis | maintenance of location in cell | multicellular organismal process | regulation of choline O-acetyltransferase activity | regulation of phosphorus metabolic process
GO Cellular Component
Golgi stack | intracellular membrane-bounded organelle | late endosome | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | multivesicular body | neuronal cell body | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear envelope lumen | Golgi apparatus | recycling endosome | Golgi cisterna | endomembrane system | nuclear envelope | vesicle | endosome | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | membrane-enclosed lumen | early endosome | trans-Golgi network | intracellular vesicle | intracellular | membrane
