QuickView for SORT1;jsessionid=0691687802177092AFD76064F0A81003;jsessionid=61EBDB2149DEE29FED3F87F88FC5236B;jsessionid=F27D326D9C0DDDA44F12100AE77F18DF (gene)
- Gene Symbol:
- Sort1
Rattus norvegicus - Full name:
- sortilin 1
- Synonyms:
- Nt3, Nts3, sortilin, NTR3, glycoprotein 110, gp110, neurotensin receptor 3
- Genomic Location:
- Chr 2: 203852955-203928178
- Description:
-
may be involved in sorting lumenal proteins in the trans-Golgi
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AAANWWTGC_UNKNOWN , CP2_01 , SRY_01 , AP1FJ_Q2 , NFY_Q6 , TGIF_01 , ATF3_Q6 , ALPHACP1_01 , E12_Q6 , MYOGENIN_Q6
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-125 , Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-146 , Predicted Gene Targets for miR-189 , Predicted Gene Targets for miR-9 , Predicted Gene Targets for miR-96 , Predicted Gene Targets for miR-182 , Predicted Gene Targets for miR-410 , Predicted Gene Targets for miR-504
| Transcripts Names |
|---|
| XM_342317 |
| XM_001076150 |
| XM_001070445 |
| XM_001070486 |
| NM_031767 |
| XM_006233195 |
| XM_006233196 |
| XM_006233194 |
GO Molecular Function
nerve growth factor binding | neurotrophin binding | neurotensin receptor activity, non-G-protein coupled | transmembrane signaling receptor activity | enzyme binding | G-protein coupled receptor activity | neuropeptide receptor activity | growth factor binding | signaling receptor activity | G-protein coupled neurotensin receptor activity | protein binding | nerve growth factor receptor activity | neurotrophin receptor activity | peptide receptor activity | G-protein coupled peptide receptor activity
GO Biological Process
positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of lipase activity | establishment of localization | response to hormone | negative regulation of cellular process | cell differentiation | negative regulation of fat cell differentiation | intracellular transport | cellular process | neuropeptide signaling pathway | endosome transport via multivesicular body sorting pathway | localization | extrinsic apoptotic signaling pathway | protein transport | macromolecule localization | response to growth factor | positive regulation of epithelial cell apoptotic process | establishment of localization in cell | response to peptide hormone | regulation of fat cell differentiation | cytosolic transport | regulation of cell differentiation | muscle structure development | muscle cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | response to nerve growth factor | regulation of lipoprotein lipase activity | cellular component organization | G-protein coupled receptor activity | Golgi to endosome transport | response to stimulus | lysosomal transport | nerve growth factor signaling pathway | endosomal transport | intracellular protein transport | monosaccharide transmembrane transport | vacuolar transport | response to peptide | programmed cell death | cellular localization | neuropeptide receptor activity | extrinsic apoptotic signaling pathway via death domain receptors | G-protein coupled receptor signaling pathway | response to nitrogen compound | apoptotic process | multicellular organism development | negative regulation of catalytic activity | regulation of catalytic activity | cellular response to nerve growth factor stimulus | post-Golgi vesicle-mediated transport | endosome to lysosome transport | regulation of gene expression | organic substance transport | plasma membrane to endosome transport | enzyme linked receptor protein signaling pathway | peptide transport | hexose transmembrane transport | vesicle-mediated transport | negative regulation of lipoprotein lipase activity | neurotrophin signaling pathway | regulation of epithelial cell apoptotic process | cell communication | G-protein coupled neurotensin receptor activity | Golgi vesicle transport | carbohydrate transport | striated muscle cell differentiation | apoptotic signaling pathway | carbohydrate transmembrane transport | nerve growth factor receptor activity | response to organic substance | neurotrophin TRK receptor signaling pathway | import into cell | response to insulin | anatomical structure development | cell surface receptor signaling pathway | cellular protein localization | glucose import | amide transport | endocytosis | positive regulation of cell death | cell death | positive regulation of programmed cell death | neurotrophin receptor activity | establishment of protein localization | vesicle organization | glucose transmembrane transport | negative regulation of molecular function | transmembrane transport | signaling | G-protein coupled peptide receptor activity | myotube differentiation | protein localization | cellular macromolecule localization | regulation of developmental process | developmental process | organelle organization | response to organonitrogen compound | negative regulation of hydrolase activity | transmembrane receptor protein tyrosine kinase signaling pathway | ossification | cellular response to organic substance | regulation of cell death | negative regulation of cell differentiation | multivesicular body sorting pathway | signal transduction | cellular response to growth factor stimulus | multicellular organismal process
GO Cellular Component
integral component of membrane | Golgi stack | dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | organelle membrane | clathrin-coated vesicle | nuclear membrane | cytoplasmic vesicle | cell body | cell | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | dendritic tree | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | cell projection | Golgi cisterna | endomembrane system | endoplasmic reticulum membrane | plasma membrane | nuclear envelope | Golgi-associated vesicle | vacuole | vesicle | transport vesicle | perinuclear region of cytoplasm | clathrin-coated pit | lytic vacuole | Golgi cisterna membrane | Golgi membrane | endosome | membrane-bounded organelle | nucleus | organelle | vesicle membrane | lysosome | cell periphery | early endosome | trans-Golgi network transport vesicle | cytosol | intracellular vesicle | cell surface | intracellular | lysosomal membrane | membrane | cytoplasmic vesicle membrane | vacuolar membrane | coated vesicle
