QuickView for SUFU;jsessionid=CB0B649FC3076049C141AB19D14CB00B;jsessionid=A492FEE5ABEF2ABFC0FE804A8F14CD47;jsessionid=CA10E8FACF0D90157D374DE9B0500DD8 (gene)

Gene Symbol:

SUFU Homo sapiens

Full name:

SUFU negative regulator of hedgehog signaling

Synonyms:

JBTS32, PRO1280, SUFUH, SUFUXL, suppressor of fused homolog

Genomic Location:

Chr 10: 104253754-104383199

Description:

The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicin...

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The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  GATA1_01 ,  GTGACTT_MIR224 ,  GGGAGGRR_MAZ_Q6 ,  GGATTA_PITX2_Q2 ,  GTCAGGA_MIR378 ,  TGCGCANK_UNKNOWN ,  EVI1_05 ,  ATGCTGC_MIR103_MIR107 ,  ACTAYRNNNCCCR_UNKNOWN ,  GATA1_02 ,  NRF1_Q6 ,  AP2_Q6 ,  ARGGGTTAA_UNKNOWN ,  AP1_Q2 ,  TGACAGNY_MEIS1_01 ,  WCAANNNYCAG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  SMAD_Q6 ,  CTGTTAC_MIR194 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  NFKB_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-378

miRNA binding sites
(Source: miRecords):

hsa-miR-378* Targeted Genes

Cytogenetic Map:

10q24.32

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