QuickView for SYK;jsessionid=294EDDCCC7989D0B34A361E2CB0E8FAD;jsessionid=00BA2A3E0163D9DA1BB9F02A1317AFA4;jsessionid=3CD7EDBD32D53154EB5EFFAB75C02CA1 (gene)
- Gene Symbol:
- Syk
Rattus norvegicus - Full name:
- spleen associated tyrosine kinase
- Synonyms:
- p72syk, tyrosine-protein kinase SYK, spleen tyrosine kinase
- Genomic Location:
- Chr 17: 18440672-18511780
- Description:
-
plays a role in cCbl-mediated ubiquitination and down-regulation by protein degradation of FcepsilonRI, a high affinity receptor for IgE
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
GO Molecular Function
protein phosphorylated amino acid binding | kinase binding | protein kinase binding | enzyme binding | protein-containing complex binding | phosphotyrosine residue binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | Toll-like receptor binding | protein serine/threonine kinase activity | catalytic activity | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein tyrosine kinase activity | protein binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding | SH2 domain binding
GO Biological Process
positive regulation of immune response | regulation of JUN kinase activity | regulation of ERK1 and ERK2 cascade | adaptive immune response | positive regulation of macromolecule biosynthetic process | exocytosis | leukotriene biosynthetic process | response to cytokine | leukotriene metabolic process | positive regulation of cellular component organization | regulation of B cell activation | cell motility | immune response-regulating signaling pathway | neutrophil activation | regulation of cellular localization | intracellular signal transduction | regulation of localization | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | defense response to other organism | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | platelet degranulation | integrin-mediated signaling pathway | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of protein secretion | intracellular transport | regulation of lipid transport | regulation of neutrophil degranulation | blood vessel morphogenesis | positive regulation of T cell differentiation | regulation of bone remodeling | positive regulation of cellular biosynthetic process | cellular process | production of molecular mediator involved in inflammatory response | secretion | lymphocyte differentiation | regulation of cytokine biosynthetic process | localization | interleukin-3-mediated signaling pathway | regulation of calcium-mediated signaling | protein transport | positive regulation of immune effector process | regulation of platelet aggregation | immune system development | positive regulation of protein kinase activity | macromolecule localization | regulation of response to cytokine stimulus | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | granulocyte chemotaxis | establishment of localization in cell | regulation of cell differentiation | cellular response to low-density lipoprotein particle stimulus | regulation of platelet activation | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | protein import into nucleus | positive regulation of cellular protein metabolic process | positive regulation of cell adhesion mediated by integrin | icosanoid biosynthetic process | positive regulation of interleukin-4 production | regulation of mast cell degranulation | MAPK cascade | T cell activation | regulation of peptide secretion | regulation of type I interferon production | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | vasculature development | JNK cascade | neutrophil chemotaxis | regulation of peptidyl-tyrosine phosphorylation | serotonin secretion by platelet | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | intracellular protein transport | leukocyte activation involved in immune response | regulation of receptor internalization | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of mast cell degranulation | tube morphogenesis | positive regulation of cell-cell adhesion | protein localization to nucleus | protein serine/threonine kinase activity | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | cellular localization | secretion by cell | organic hydroxy compound transport | positive regulation of cytokine secretion | cardiovascular system development | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | positive regulation of T cell activation | immune response-activating signal transduction | regulation of phagocytosis | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | hemopoiesis | regulation of wound healing | protein modification process | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | positive regulation of B cell differentiation | cell chemotaxis | B cell receptor signaling pathway | activation of protein kinase activity | regulation of intracellular transport | regulation of lymphocyte differentiation | blood vessel development | stress-activated protein kinase signaling cascade | leukocyte migration | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | leukocyte differentiation | positive regulation of exocytosis | regulation of cellular response to stress | locomotion | response to nitrogen compound | positive regulation of mononuclear cell proliferation | regulation of superoxide metabolic process | response to external biotic stimulus | system development | regulation of interleukin-4 production | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lymph vessel development | regulation of phosphorylation | positive regulation of gamma-delta T cell differentiation | regulation of T cell activation | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | positive regulation of secretion | organic substance transport | cellular response to stress | regulation of protein autophosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | regulation of blood coagulation | regulation of mast cell activation | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of JNK cascade | small molecule metabolic process | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | alpha-beta T cell differentiation | protein localization to organelle | import into nucleus | positive regulation of cell differentiation | positive regulation of calcium-mediated signaling | macrophage activation involved in immune response | cellular response to cytokine stimulus | biosynthetic process | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | regulation of gamma-delta T cell differentiation | angiogenesis | regulation of cell adhesion mediated by integrin | phosphorylation | regulated exocytosis | positive regulation of peptidyl-tyrosine autophosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | positive regulation of regulated secretory pathway | protein import | response to bacterium | response to fungus | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of alpha-beta T cell differentiation | receptor internalization | inflammatory response | regulation of tumor necrosis factor-mediated signaling pathway | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | leukocyte chemotaxis | defense response to bacterium | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | serotonin transport | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | positive regulation of B cell activation | positive regulation of transport | cellular response to lipoprotein particle stimulus | carboxylic acid metabolic process | lymphocyte activation | protein tyrosine kinase activity | positive regulation of molecular function | regulation of cytokine secretion | activation of MAPK activity | T cell differentiation | activation of immune response | response to molecule of fungal origin | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | T cell selection | response to organic substance | regulation of homotypic cell-cell adhesion | regulation of hemopoiesis | regulation of kinase activity | import into cell | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | regulation of exocytosis | collagen-activated tyrosine kinase receptor signaling pathway | establishment of protein localization to organelle | anatomical structure development | cell surface receptor signaling pathway | leukocyte cell-cell adhesion | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | cellular protein localization | regulation of bone resorption | regulation of tissue remodeling | amide transport | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | cell adhesion | regulation of arachidonic acid secretion | macrophage activation | immune response | protein kinase activity | positive regulation of mast cell activation | organic substance metabolic process | regulation of B cell differentiation | nuclear transport | beta selection | animal organ development | regulation of cell activation | regulation of protein secretion | positive regulation of kinase activity | alpha-beta T cell activation | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | establishment of protein localization | cell-cell adhesion | positive regulation of cytokine production | regulation of regulated secretory pathway | positive regulation of intracellular transport | regulation of JNK cascade | positive regulation of interleukin-3 biosynthetic process | cell activation | positive regulation of MAPK cascade | collagen-activated signaling pathway | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | icosanoid metabolic process | regulation of response to wounding | non-membrane spanning protein tyrosine kinase activity | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of endocytosis | regulation of T cell proliferation | cellular response to molecule of fungal origin | protein localization | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | cation transport | cellular macromolecule localization | positive regulation of MAP kinase activity | positive regulation of receptor internalization | response to biotic stimulus | nucleocytoplasmic transport | positive regulation of tissue remodeling | ammonium transport | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | kinase activity | developmental process | positive regulation of alpha-beta T cell activation | peptidyl-serine phosphorylation | cellular protein modification process | monoamine transport | positive regulation of protein autophosphorylation | tube development | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | regulation of superoxide anion generation | innate immune response | neurotransmitter transport | receptor metabolic process | regulation of fatty acid transport | positive regulation of bone resorption | serotonin secretion | response to organonitrogen compound | regulation of anion transport | positive regulation of JUN kinase activity | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | ion transport | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | activation of JUN kinase activity | positive regulation of type I interferon production | neutrophil migration | circulatory system development | chemotaxis | positive regulation of endocytosis | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gamma-delta T cell activation | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | T cell receptor complex | cytoplasmic vesicle | cell | plasma membrane protein complex | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | plasma membrane | vesicle | membrane-bounded organelle | nucleus | organelle | cell periphery | B cell receptor complex | early phagosome | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | phagocytic vesicle
