QuickView for Sirt1;jsessionid=CBB236F09AD7495731C4F11D493F46A7;jsessionid=D0D3039CD5D64B79D329A0B96A2421A3;jsessionid=6066F3F489B8A2B0559CC0A3AC658FB0 (gene)
- Gene Symbol:
- sir-2.1
C. elegans - Full name:
- yeast SIR related
- Synonyms:
- R11A8.4, sir-2.1
- Genomic Location:
- Chr IV: 10363293-10366209
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
histone deacetylase activity (H3-K9 specific) | kinase binding | cofactor binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | hormone receptor binding | protein kinase binding | enzyme binding | mitogen-activated protein kinase binding | nucleotide binding | coenzyme binding | signaling receptor binding | hydrolase activity | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein deacetylase activity | NAD+ binding | catalytic activity | protein domain specific binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | anion binding | histone deacetylase activity | p53 binding | bHLH transcription factor binding | transcription corepressor activity | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | protein binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | NAD binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | transcription coregulator activity | metal ion binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding | NAD-dependent histone deacetylase activity (H3-K9 specific)
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | histone deacetylase activity (H3-K9 specific) | intracellular signal transduction | larval development | peptidyl-amino acid modification | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | histone modification | intrinsic apoptotic signaling pathway in response to DNA damage | histone H3 acetylation | histone deacetylation | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | programmed cell death | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | protein deacetylase activity | cellular biosynthetic process | macromolecule modification | histone H3 deacetylation | regulation of nucleic acid-templated transcription | apoptotic process | nitrogen compound metabolic process | multicellular organism development | protein acetylation | NAD-dependent protein deacetylase activity | cellular response to DNA damage stimulus | regulation of gene expression | histone deacetylase activity | histone H3-K9 acetylation | cellular response to stress | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | protein deacetylation | aromatic compound biosynthetic process | post-embryonic development | NAD-dependent histone deacetylase activity | cell communication | regulation of cellular metabolic process | histone H3-K9 deacetylation | regulation of RNA metabolic process | apoptotic signaling pathway | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | peptidyl-lysine modification | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | gene expression | transcription, DNA-templated | multicellular organism aging | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | internal protein amino acid acetylation | determination of adult lifespan | histone H3-K9 modification | cellular protein metabolic process | cellular macromolecule biosynthetic process | developmental process | organelle organization | nematode larval development | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | dauer larval development | positive regulation of metabolic process | chromosome organization | cellular metabolic process | aging | signal transduction | NAD-dependent histone deacetylase activity (H3-K9 specific) | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear euchromatin | organelle inner membrane | chromosome | intracellular membrane-bounded organelle | rDNA heterochromatin | organelle membrane | nuclear membrane | cell | nuclear lumen | nuclear inner membrane | cytoplasm | intracellular organelle | euchromatin | endomembrane system | nucleoplasm | nuclear envelope | chromatin | nuclear chromosome | perinuclear region of cytoplasm | chromosome, telomeric region | membrane-bounded organelle | heterochromatin | nucleus | organelle | nuclear heterochromatin | membrane-enclosed lumen | nuclear chromatin | nuclear chromosome, telomeric region | intracellular | membrane
