QuickView for Sox2;jsessionid=5D6C787EF153F66DB750363068080036;jsessionid=CE2A4A9A3CBB7752FD28CBDE323883D5 (gene)

Gene Symbol:

Sox2 Mus musculus

Full name:

SRY (sex determining region Y)-box 2

Synonyms:

Sox-2, lcc, ysb, transcription factor SOX-2, SRY-box containing gene 2

Genomic Location:

Chr 3: 34548927-34551383

Description:

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations i...

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This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot).

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  MEF2_01 ,  SOX5_01 ,  GATA1_01 ,  HFH1_01 ,  HNF3B_01 ,  ACTWSNACTNY_UNKNOWN ,  LYF1_01 ,  CEBP_01 ,  SRY_02 ,  AP2_Q6 ,  NF1_Q6 ,  SP1_Q6 ,  NFY_C ,  CCAATNNSNNNGCG_UNKNOWN ,  NFY_01 ,  FREAC7_01 ,  HFH8_01 ,  OCT1_B ,  AMEF2_Q6 ,  HMEF2_Q6 ,  SOX9_B1 ,  FOXJ2_02 ,  HIF1_Q5 ,  FOXO1_01 ,  CTGCAGY_UNKNOWN ,  EFC_Q6 ,  GATA4_Q3 ,  MAF_Q6 ,  TFIIA_Q6 ,  HP1SITEFACTOR_Q6 ,  OSF2_Q6 ,  GCTNWTTGK_UNKNOWN ,  ETS_Q4 ,  HIF1_Q3 ,  AP2_Q3 ,  NF1_Q6_01 ,  AP2_Q6_01 ,  AP4_Q6_01 ,  SP1_Q4_01 ,  SP1_Q2_01 ,  ER_Q6_02 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  TTGCCAA_MIR182 ,  TAGCTTT_MIR9 ,  CCATCCA_MIR432 ,  GCAAAAA_MIR129 ,  ATAAGCT_MIR21 ,  CGCAAAA_MIR450 ,  ACCAATC_MIR509 ,  RRAGTTGT_UNKNOWN ,  TCCATTKW_UNKNOWN ,  WCAANNNYCAG_UNKNOWN ,  WTGAAAT_UNKNOWN ,  YATTNATC_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  CAGCTG_AP4_Q5 ,  TTGTTT_FOXO4_01 ,  RTAAACA_FREAC2_01 ,  MGGAAGTG_GABP_B ,  TGTTTGY_HNF3_Q6 ,  CTTTGT_LEF1_Q2 ,  YTATTTTNR_MEF2_02 ,  TGACAGNY_MEIS1_01 ,  GCANCTGNY_MYOD_Q6 ,  TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  CATTGTYY_SOX9_B1 ,  GGGCGGR_SP1_Q6 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-493-5p

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