QuickView for TER94;jsessionid=DCAD6374D92ACB07281E0D5163D1D634;jsessionid=261DCA912F0CE134F16C576CBC4621C7 (gene)

Gene Symbol:

VCP Homo sapiens

Full name:

valosin containing protein

Synonyms:

CDC48, TERA, p97, transitional endoplasmic reticulum ATPase, 15S Mg(2+)-ATPase p97 subunit, TER ATPase

Genomic Location:

Chr 9: 35046560-35062564

Description:

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extract...

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This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TCTGGAC_MIR198 ,  GATTGGY_NFY_Q6_01 ,  FREAC7_01 ,  ATF6_01 ,  TGANNYRGCA_TCF11MAFG_01 ,  TTTTGAG_MIR373 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  TTCYRGAA_UNKNOWN ,  GAGCTGG_MIR337 ,  GCAAAAA_MIR129 ,  NFY_01 ,  NFY_Q6 ,  NRF2_Q4 ,  GACAGGG_MIR339 ,  GR_01 ,  CCAGGGG_MIR331 ,  ZF5_B ,  GCTNWTTGK_UNKNOWN ,  RRCCGTTA_UNKNOWN ,  CP2_01 ,  TCF11MAFG_01 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

9p13.3

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