QuickView for TER94;jsessionid=DCAD6374D92ACB07281E0D5163D1D634;jsessionid=194C4122D84BD54EB5ED12200663520D (gene)
- Gene Symbol:
- CDC48
Saccharomyces cerevisiae - Full name:
- ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
- Synonyms:
- CDC48, CDC48, YDL126C
- Genomic Location:
- Chr IV: 236157-238664
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CP2_01 , NFY_Q6 , TCF11MAFG_01 , TCF11_01 , NFY_01 , FREAC7_01 , ZF5_B , ATF6_01 , ALPHACP1_01 , GCTNWTTGK_UNKNOWN
GO Molecular Function
ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | ubiquitin binding | molecular function regulator | catalytic activity | polyubiquitin modification-dependent protein binding | ATP binding | anion binding | adenyl nucleotide binding | modification-dependent protein binding | nucleoside-triphosphatase activity | purine nucleotide binding | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | hydrolase activity, acting on acid anhydrides | protein phosphatase regulator activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | phosphatase regulator activity
GO Biological Process
RNA metabolic process | stress-induced homeostatically regulated protein degradation pathway | regulation of dephosphorylation | response to endoplasmic reticulum stress | microtubule cytoskeleton organization involved in mitosis | positive regulation of cellular component organization | regulation of cellular localization | proteolysis | protein localization to vacuole | regulation of localization | organelle fusion | macroautophagy | establishment of localization | selective autophagy | negative regulation of cellular process | membrane fusion | regulation of phosphatase activity | response to metal ion | microtubule cytoskeleton organization | regulation of histone H2B ubiquitination | response to misfolded protein | ER-associated misfolded protein catabolic process | regulation of organelle organization | membrane organization | intracellular transport | negative regulation of DNA metabolic process | microtubule-based process | cellular process | negative regulation of DNA biosynthetic process | organic substance catabolic process | endosome transport via multivesicular body sorting pathway | nuclear protein quality control by the ubiquitin-proteasome system | localization | proteolysis involved in cellular protein catabolic process | protein transport | macromolecule localization | regulation of histone modification | nonfunctional rRNA decay | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | response to topologically incorrect protein | cellular aromatic compound metabolic process | cellular component organization | cellular response to topologically incorrect protein | cellular response to metal ion | lysosomal microautophagy | response to stimulus | regulation of cellular protein localization | chromosome segregation | positive regulation of protein metabolic process | mitotic spindle organization | endosomal transport | sister chromatid biorientation | response to stress | intracellular protein transport | positive regulation of cellular protein localization | vacuolar transport | regulation of protein ubiquitination | cellular response to inorganic substance | cellular protein catabolic process | cellular localization | cellular response to cadmium ion | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | negative regulation of metabolic process | nucleobase-containing compound catabolic process | molecular function regulator | regulation of histone ubiquitination | response to nitrogen compound | nitrogen compound metabolic process | positive regulation of organelle organization | negative regulation of catalytic activity | sister chromatid segregation | regulation of catalytic activity | positive regulation of chromosome organization | SCF complex disassembly in response to cadmium stress | organic substance transport | cellular response to stress | cell cycle | protein catabolic process | RNA catabolic process | positive regulation of cellular metabolic process | regulation of telomerase activity | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | peptide transport | vesicle-mediated transport | protein localization to organelle | positive regulation of protein localization to nucleus | response to cadmium ion | regulation of cellular protein metabolic process | positive regulation of histone H2B ubiquitination | rRNA metabolic process | rRNA catabolic process | autophagy | nuclear chromosome segregation | regulation of cellular metabolic process | regulation of protein metabolic process | aromatic compound catabolic process | cellular protein complex disassembly | proteasome-mediated ubiquitin-dependent protein catabolic process | organelle disassembly | ERAD pathway | protein metabolic process | positive regulation of protein modification process | response to organic substance | ribophagy | regulation of protein dephosphorylation | late endosome to vacuole transport via multivesicular body sorting pathway | cellular macromolecule catabolic process | establishment of protein localization to organelle | piecemeal microautophagy of the nucleus | mitotic cell cycle | metabolic process | ribosome-associated ubiquitin-dependent protein catabolic process | endoplasmic reticulum membrane fusion | protein quality control for misfolded or incompletely synthesized proteins | cellular protein localization | amide transport | nucleobase-containing compound metabolic process | mitochondria-associated ubiquitin-dependent protein catabolic process | organic substance metabolic process | negative regulation of biosynthetic process | positive regulation of histone modification | protein phosphatase regulator activity | regulation of phosphate metabolic process | establishment of protein localization to vacuole | cytoskeleton organization | regulation of chromosome organization | late endosome to vacuole transport | establishment of protein localization | positive regulation of histone ubiquitination | attachment of spindle microtubules to kinetochore | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | negative regulation of molecular function | protein localization | protein-containing complex disassembly | cellular protein metabolic process | enzyme regulator activity | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | cellular macromolecule localization | regulation of phosphoprotein phosphatase activity | organelle organization | regulation of DNA biosynthetic process | ncRNA metabolic process | aggrephagy | response to organonitrogen compound | heterocycle metabolic process | ubiquitin-dependent ERAD pathway | cytoplasm protein quality control by the ubiquitin-proteasome system | positive regulation of metabolic process | chromosome organization | cellular response to misfolded protein | cellular metabolic process | cellular response to organic substance | regulation of protein localization | modification-dependent protein catabolic process | spindle organization | protein exit from endoplasmic reticulum | autophagosome maturation | positive regulation of protein ubiquitination | negative regulation of telomerase activity | regulation of cellular component organization | retrograde protein transport, ER to cytosol | multivesicular body sorting pathway | mitotic spindle disassembly | phosphatase regulator activity | macromolecule metabolic process | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
cytosolic ribosome | RQC complex | intracellular membrane-bounded organelle | catalytic complex | ER ubiquitin ligase complex | organelle membrane | cell | organelle outer membrane | Hrd1p ubiquitin ligase ERAD-L complex | cytoplasm | outer mitochondrial membrane protein complex | intracellular organelle | ribosome | endoplasmic reticulum | ubiquitin ligase complex | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | mating projection | endomembrane system | endoplasmic reticulum membrane | ribonucleoprotein complex | transferase complex | Hrd1p ubiquitin ligase complex | mitochondrion | site of polarized growth | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | cytosolic large ribosomal subunit | mating projection tip | mitochondrial envelope | VCP-NPL4-UFD1 AAA ATPase complex | Doa10p ubiquitin ligase complex | outer membrane | Cdc48p-Npl4p-Vms1p AAA ATPase complex | large ribosomal subunit | mitochondrial membrane | cytosol | cell tip | intracellular | cytoplasmic ubiquitin ligase complex | membrane
