QuickView for TGFB2;jsessionid=E7CF04785ADA749F1245B60D0B569A0F;jsessionid=4953B7B0FC1205EC2D00CC414A5FDAD2 (gene)
- Gene Symbol:
- Tgfb2
Rattus norvegicus - Full name:
- transforming growth factor, beta 2
- Synonyms:
- TGF-B2, transforming growth factor beta-2, TGF beta 2 protein, TGF-beta-2
- Genomic Location:
- Chr 13: 102718703-102818768
- Description:
-
binds the transforming growth factor-beta receptor; plays a role in regulation of cell growth and proliferation; may be involved in mesenchymal-epithelial cell interactions during development
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
peptide binding | amyloid-beta binding | transforming growth factor beta receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | protein N-terminus binding | amide binding | identical protein binding | protein heterodimerization activity | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor ligand activity | cytokine activity | type III transforming growth factor beta receptor binding | type II transforming growth factor beta receptor binding
GO Biological Process
positive regulation of immune response | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of heart contraction | response to extracellular stimulus | brain development | limb development | molting cycle | SMAD protein signal transduction | response to radiation | cell morphogenesis | regulation of extrinsic apoptotic signaling pathway in absence of ligand | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of dephosphorylation | response to nutrient levels | negative regulation of immune system process | negative regulation of macrophage cytokine production | positive regulation of blood circulation | epidermis morphogenesis | extracellular structure organization | response to cytokine | positive regulation of cellular component organization | cell motility | pharyngeal system development | neuron projection morphogenesis | cranial skeletal system development | developmental process involved in reproduction | regulation of cellular localization | muscle tissue development | positive regulation of apoptotic process | regulation of integrin biosynthetic process | regulation of localization | heart trabecula morphogenesis | catechol-containing compound metabolic process | morphogenesis of an epithelium | gonad development | regulation of programmed cell death | eye development | regulation of immune system process | response to hormone | negative regulation of cellular process | positive regulation of developmental process | regulation of phosphatase activity | embryonic appendage morphogenesis | bone development | cell differentiation | respiratory tube development | nervous system development | epithelial to mesenchymal transition | response to drug | regulation of extracellular matrix organization | organ growth | cell part morphogenesis | neurogenesis | pulmonary valve development | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | mesenchyme development | salivary gland morphogenesis | cardiac atrium morphogenesis | phenol-containing compound metabolic process | blood vessel morphogenesis | regulation of neuron death | neural retina development | positive regulation of cellular biosynthetic process | cellular process | ascending aorta morphogenesis | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | limb morphogenesis | tissue remodeling | heart morphogenesis | negative regulation of signaling | developmental growth | neuron development | cranial suture morphogenesis | reproductive system development | response to progesterone | response to estradiol | positive regulation of timing of catagen | positive regulation of epithelial to mesenchymal transition | female pregnancy | positive regulation of pathway-restricted SMAD protein phosphorylation | immune system development | positive regulation of extracellular matrix disassembly | positive regulation of protein kinase activity | negative regulation of apoptotic process | response to hypoxia | axon guidance | negative regulation of alkaline phosphatase activity | positive regulation of T cell apoptotic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | granulocyte chemotaxis | pathway-restricted SMAD protein phosphorylation | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | muscle structure development | ventricular septum morphogenesis | skeletal muscle organ development | regulation of lymphocyte apoptotic process | regulation of angiogenesis | regulation of immune response | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | head morphogenesis | gliogenesis | positive regulation of stress-activated MAPK cascade | positive regulation of extracellular matrix organization | positive regulation of activation-induced cell death of T cells | organic cyclic compound metabolic process | trabecula morphogenesis | positive regulation of cellular protein metabolic process | positive regulation of cell adhesion mediated by integrin | negative regulation of phosphatase activity | positive regulation of hair cycle | epithelium development | cellular aromatic compound metabolic process | cellular component organization | ventricular trabecula myocardium morphogenesis | response to transforming growth factor beta | regulation of cell division | urogenital system development | positive regulation of epithelial cell migration | development of primary sexual characteristics | head development | thyroid gland development | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | muscle organ morphogenesis | regulation of vasculature development | response to stimulus | cardiac right ventricle morphogenesis | vasculature development | cell morphogenesis involved in neuron differentiation | cartilage condensation | negative regulation of epithelial to mesenchymal transition | regulation of cellular protein localization | embryonic limb morphogenesis | regulation of extracellular matrix disassembly | respiratory system development | neutrophil chemotaxis | positive regulation of cardioblast differentiation | blood vessel remodeling | embryonic epithelial tube formation | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | endocardial cushion fusion | response to cold | positive regulation of phosphatidylinositol 3-kinase signaling | gland morphogenesis | response to stress | neuron projection guidance | positive regulation of cellular protein localization | skeletal muscle tissue development | craniofacial suture morphogenesis | regulation of cell proliferation | roof of mouth development | negative regulation of angiogenesis | response to laminar fluid shear stress | cardiac muscle cell proliferation | tube morphogenesis | regulation of blood circulation | cardiac muscle tissue development | muscle tissue morphogenesis | programmed cell death | supramolecular fiber organization | epithelial tube formation | reproduction | atrioventricular valve morphogenesis | embryonic skeletal system development | cardiovascular system development | response to temperature stimulus | cardiac ventricle morphogenesis | extracellular matrix organization | negative regulation of transport | catecholamine biosynthetic process | regulation of protein transport | response to vitamin D | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of apoptotic process involved in outflow tract morphogenesis | hemopoiesis | protein modification process | cartilage development | positive regulation of hair follicle development | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | heart growth | macromolecule modification | positive regulation of GTP binding | dopamine metabolic process | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | cell chemotaxis | activation of protein kinase activity | molecular function regulator | blood vessel development | leukocyte migration | pulmonary valve morphogenesis | neuron fate commitment | frontal suture morphogenesis | embryonic neurocranium morphogenesis | regulation of nucleic acid-templated transcription | somatic stem cell division | positive regulation of peptide secretion | regulation of cellular response to stress | locomotion | organic hydroxy compound metabolic process | response to nitrogen compound | apoptotic process | regulation of calcium ion transport into cytosol | endocardial cushion development | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of growth | negative regulation of phosphate metabolic process | regulation of cartilage development | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of phosphorylation | regulation of ossification | hair follicle morphogenesis | embryonic digestive tract development | wound healing | cardiac epithelial to mesenchymal transition | artery development | positive regulation of cell cycle | regulation of small GTPase mediated signal transduction | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | pancreas development | axon development | positive regulation of secretion | neural tube closure | outflow tract morphogenesis | response to ketone | response to lipid | cell cycle | endocardial cushion morphogenesis | regulation of epidermis development | stem cell division | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | animal organ morphogenesis | regulation of pri-miRNA transcription by RNA polymerase II | regulation of protein localization to nucleus | positive regulation of Notch signaling pathway | regulation of nitrogen compound metabolic process | regulation of cell migration | glial cell migration | regulation of Notch signaling pathway | enzyme linked receptor protein signaling pathway | regulation of timing of catagen | cardiac atrium development | negative regulation of release of sequestered calcium ion into cytosol | positive regulation of intracellular signal transduction | neural tube formation | cardiocyte differentiation | regulation of hair follicle development | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | dopamine biosynthetic process | axonogenesis | positive regulation of cell differentiation | regulation of release of sequestered calcium ion into cytosol | stem cell differentiation | positive regulation of cell migration | negative regulation of ion transmembrane transport | cell proliferation | pharyngeal arch artery morphogenesis | positive regulation of protein localization to nucleus | biosynthetic process | cell division | neural tube development | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of immune response | positive regulation of ossification | hindbrain development | mesenchyme morphogenesis | regulation of cell adhesion mediated by integrin | phosphorylation | positive regulation of pri-miRNA transcription by RNA polymerase II | negative regulation of ion transport | cardiac septum morphogenesis | digestive tract development | regulation of calcium ion transmembrane transport | regulation of complement-dependent cytotoxicity | positive regulation of neuron death | epidermis development | positive regulation of leukocyte apoptotic process | septum primum development | regulation of apoptotic signaling pathway | skin development | regulation of heart contraction | endocrine system development | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | sensory organ development | response to estrogen | chordate embryonic development | striated muscle tissue development | positive regulation of extrinsic apoptotic signaling pathway | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of neuron apoptotic process | skeletal system morphogenesis | semi-lunar valve development | regulation of T cell apoptotic process | positive regulation of sequestering of calcium ion | negative regulation of calcium ion transport | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | leukocyte chemotaxis | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | bone morphogenesis | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of stem cell differentiation | renal system development | positive regulation of transport | response to retinoic acid | negative regulation of cell growth | apoptotic signaling pathway | negative regulation of calcium ion transport into cytosol | embryonic morphogenesis | cardiac muscle tissue growth | drug metabolic process | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | secondary palate development | neuron differentiation | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | regulation of signaling receptor activity | receptor regulator activity | development of primary male sexual characteristics | heart valve development | ventricular septum development | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of establishment of protein localization | cardiac ventricle development | positive regulation of protein modification process | regulation of growth | hair cycle | response to organic substance | gland development | tissue morphogenesis | artery morphogenesis | digestive system development | cell cycle arrest | retina development in camera-type eye | catecholamine metabolic process | regulation of kinase activity | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | ventricular cardiac muscle tissue development | positive regulation of neuron apoptotic process | face morphogenesis | anatomical structure development | cell surface receptor signaling pathway | aorta development | growth factor activity | embryonic skeletal system morphogenesis | cell projection organization | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of programmed cell death | embryonic organ development | male gonad development | ear development | atrial septum primum morphogenesis | hair cycle process | regulation of secretion | positive regulation of cell death | cell adhesion | regulation of GTP binding | morphogenesis of embryonic epithelium | receptor ligand activity | neuron projection development | cytokine activity | heart valve morphogenesis | organic substance metabolic process | regulation of sequestering of calcium ion | connective tissue development | cell death | response to vitamin | negative regulation of gene expression | animal organ development | negative regulation of small GTPase mediated signal transduction | regulation of protein secretion | regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | negative regulation of Ras protein signal transduction | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of heart morphogenesis | skin epidermis development | regulation of phosphate metabolic process | regulation of ion transmembrane transport | regulation of transforming growth factor beta2 production | positive regulation of binding | cell-cell adhesion | atrioventricular valve development | positive regulation of stem cell differentiation | positive regulation of MAPK cascade | aorta morphogenesis | lung development | positive regulation of lymphocyte apoptotic process | atrial septum development | positive regulation of protein transport | camera-type eye development | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | uterus development | negative regulation of cartilage development | negative regulation of cell cycle | regulation of epithelial cell migration | response to fluid shear stress | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | muscle cell proliferation | negative regulation of signal transduction | signaling | positive regulation of growth | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | collagen fibril organization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | cardioblast differentiation | regulation of cytokine production | regulation of Ras protein signal transduction | anatomical structure morphogenesis | reproductive structure development | regulation of developmental process | regulation of ion transport | developmental process | regulation of cell growth | regulation of calcium ion transport | cell aggregation | cardiac septum development | cellular protein modification process | tube development | regulation of transport | positive regulation of transcription, DNA-templated | membranous septum morphogenesis | negative regulation of cell proliferation | regulation of hair cycle | atrial septum morphogenesis | regulation of activation-induced cell death of T cells | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | tube closure | negative regulation of dephosphorylation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | positive regulation of epidermis development | cardiac chamber development | regulation of apoptotic process involved in development | negative regulation of hydrolase activity | tube formation | central nervous system development | cell adhesion involved in heart morphogenesis | cell-cell adhesion via plasma-membrane adhesion molecules | positive regulation of metabolic process | regulation of actin filament-based process | skeletal system development | regulation of cardioblast differentiation | immune system process | cellular metabolic process | body morphogenesis | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | sex differentiation | positive regulation of cell motility | salivary gland development | response to steroid hormone | negative regulation of cell death | neutrophil migration | circulatory system development | aging | chemotaxis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of cardiac epithelial to mesenchymal transition | positive regulation of integrin biosynthetic process | positive regulation of apoptotic signaling pathway | muscle organ development | substantia propria of cornea development | regulation of cytoskeleton organization | positive regulation of signaling | hair follicle development | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | outflow tract septum morphogenesis | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | face development | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | intracellular membrane-bounded organelle | neuron projection | extracellular matrix | basement membrane | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | Golgi apparatus | cell projection | secretory vesicle | endomembrane system | vesicle | endosome | extracellular region | membrane-bounded organelle | organelle | extracellular space | axon | trans-Golgi network | intracellular vesicle | cell surface | intracellular
