QuickView for TIF45;jsessionid=AAE3BE38E5BDC610CA0F5E424DA29986;jsessionid=4F14568DBEE0C4E67DA77BCB9B61D1B0;jsessionid=0A723A09B4CF3F40EFDC749F74820C29 (gene)

Gene Symbol:

Eif4e Mus musculus

Full name:

eukaryotic translation initiation factor 4E

Synonyms:

EG668879, Eif4e-ps, If4e, eIF-4E, eukaryotic translation initiation factor 4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein

Genomic Location:

Chr 3: 138189155-138220563

Description:

This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step ...

View Full Description

This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP4_01 ,  AACTTT_UNKNOWN ,  MYCMAX_01 ,  MAX_01 ,  USF_01 ,  USF_02 ,  PAX5_01 ,  OCT1_06 ,  AP1_Q6 ,  AP1_Q4 ,  USF_C ,  STAT_01 ,  ARNT_01 ,  NKX25_02 ,  TCF11_01 ,  VDR_Q3 ,  SPZ1_01 ,  STAT5A_01 ,  BACH2_01 ,  STAT6_01 ,  BACH1_01 ,  STAT3_02 ,  MYCMAX_03 ,  TCF4_Q5 ,  CACCCBINDINGFACTOR_Q6 ,  HFH4_01 ,  POU1F1_Q6 ,  P53_DECAMER_Q2 ,  STAT_Q6 ,  SMAD_Q6 ,  TTF1_Q6 ,  USF_Q6_01 ,  ER_Q6_01 ,  AP1_Q2_01 ,  VDR_Q6 ,  T3R_Q6 ,  ACATTCC_MIR1_MIR206 ,  CACTTTG_MIR520G_MIR520H ,  CATTTCA_MIR203 ,  GGTGAAG_MIR412 ,  GAGACTG_MIR452 ,  TTGGGAG_MIR150 ,  CTTTGTA_MIR524 ,  ACCAAAG_MIR9 ,  TGCTTTG_MIR330 ,  ATTCTTT_MIR186 ,  TGTGTGA_MIR377 ,  ATTACAT_MIR3803P ,  YATTNATC_UNKNOWN ,  YYCATTCAWW_UNKNOWN ,  TGACCTY_ERR1_Q2 ,  CTTTGA_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TGACAGNY_MEIS1_01 ,  CACGTG_MYC_Q2 ,  TGASTMAGC_NFE2_01 ,  GATTGGY_NFY_Q6_01 ,  CGTSACG_PAX3_B ,  GGGTGGRR_PAX4_03 ,  CATTGTYY_SOX9_B1 ,  TTCYNRGAA_STAT5B_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-493-5p

View More

View Less

search → result