QuickView for TIMP-1;jsessionid=DFB1FA2C5BEFB5B7DF6896A963233FC6;jsessionid=6343374556D15CCB179BB73F1E622C0B (gene)
- Gene Symbol:
- Timp1
Rattus norvegicus - Full name:
- TIMP metallopeptidase inhibitor 1
- Synonyms:
- TIMP-1, Timp, metalloproteinase inhibitor 1, tissue inhibitor of metallopeptidase 1, tissue inhibitor of metalloproteinase 1, tissue inhibitor of metalloproteinases 1
- Genomic Location:
- Chr X: 12542496-12547094
- Description:
-
acts as an inhibitor of metalloprotease activity; may play a role in vascular tissue remodeling
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
endopeptidase inhibitor activity | cation binding | enzyme binding | enzyme inhibitor activity | signaling receptor binding | molecular function regulator | ion binding | protein binding | zinc ion binding | receptor regulator activity | growth factor activity | receptor ligand activity | cytokine activity | transition metal ion binding | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | protease binding | metal ion binding
GO Biological Process
negative regulation of membrane protein ectodomain proteolysis | endopeptidase inhibitor activity | response to cytokine | regulation of localization | regulation of programmed cell death | response to hormone | negative regulation of cellular process | defense response | negative regulation of proteolysis | cellular process | regulation of trophoblast cell migration | regulation of cell motility | regulation of integrin-mediated signaling pathway | tissue remodeling | negative regulation of apoptotic process | regulation of proteolysis | negative regulation of cell migration | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | negative regulation of cell motility | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | steroid biosynthetic process | response to stimulus | enzyme inhibitor activity | response to stress | regulation of cell proliferation | response to peptide | negative regulation of metabolic process | cartilage development | molecular function regulator | response to nitrogen compound | system development | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | inflammatory response to wounding | regulation of catalytic activity | lipid metabolic process | negative regulation of peptidase activity | connective tissue replacement involved in inflammatory response wound healing | wound healing | negative regulation of metallopeptidase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cellular component movement | biosynthetic process | regulation of cellular protein metabolic process | lipid biosynthetic process | regulation of cellular metabolic process | inflammatory response | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of locomotion | wound healing involved in inflammatory response | regulation of signaling receptor activity | receptor regulator activity | response to organic substance | response to wounding | anatomical structure development | growth factor activity | metabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | receptor ligand activity | cytokine activity | organic substance metabolic process | connective tissue development | animal organ development | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | cell activation | negative regulation of protein catabolic process | negative regulation of protein metabolic process | steroid metabolic process | regulation of cell communication | negative regulation of molecular function | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | regulation of endopeptidase activity | regulation of developmental process | developmental process | response to organonitrogen compound | negative regulation of hydrolase activity | skeletal system development | regulation of cell death | negative regulation of trophoblast cell migration | negative regulation of cell death | aging | negative regulation of locomotion | regulation of signaling | negative regulation of endopeptidase activity | multicellular organismal process
GO Cellular Component
extracellular matrix | basement membrane | collagen-containing extracellular matrix | extracellular region | extracellular space
