QuickView for TIMP3;jsessionid=4B9DC4AE20B396428B1B9E1357176C89;jsessionid=7BCF46951E5930373F8EECF97014F604 (gene)
- Gene Symbol:
- Timp3
Rattus norvegicus - Full name:
- TIMP metallopeptidase inhibitor 3
- Synonyms:
- Timp-3, metalloproteinase inhibitor 3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory), tissue inhibitor of metalloproteinases 3
- Genomic Location:
- Chr 7: 19677144-19727072
- Description:
-
may inhibit metalloendopeptidase activity; may play a role in induction of apoptosis
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , IK3_01 , MYCMAX_02 , PAX5_01 , SP1_Q6 , RREB1_01 , VDR_Q3 , ZIC2_01 , ZIC3_01 , CEBPDELTA_Q6
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-101 , Predicted Gene Targets for miR-144 , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-21 , Predicted Gene Targets for miR-221 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-299-3p , Predicted Gene Targets for miR-384
GO Molecular Function
endopeptidase inhibitor activity | cation binding | enzyme binding | enzyme inhibitor activity | molecular function regulator | ion binding | protein binding | zinc ion binding | transition metal ion binding | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | protease binding | metal ion binding
GO Biological Process
response to extracellular stimulus | negative regulation of metalloendopeptidase activity | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | negative regulation of membrane protein ectodomain proteolysis | response to nutrient levels | endopeptidase inhibitor activity | negative regulation of MAPK cascade | response to cytokine | positive regulation of apoptotic process | regulation of programmed cell death | response to hormone | negative regulation of cellular process | nervous system development | response to drug | negative regulation of protein phosphorylation | negative regulation of proteolysis | response to folic acid | cellular process | negative regulation of signaling | developmental growth | regulation of proteolysis | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | negative regulation of cellular metabolic process | tissue development | regeneration | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | response to stimulus | enzyme inhibitor activity | response to stress | negative regulation of metabolic process | negative regulation of ERK1 and ERK2 cascade | molecular function regulator | response to nitrogen compound | system development | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | response to amino acid | regulation of catalytic activity | regulation of phosphorylation | negative regulation of peptidase activity | wound healing | regulation of extrinsic apoptotic signaling pathway | negative regulation of metallopeptidase activity | regulation of nitrogen compound metabolic process | response to nutrient | regulation of cellular protein metabolic process | regulation of apoptotic signaling pathway | response to estrogen | positive regulation of extrinsic apoptotic signaling pathway | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | response to organic substance | response to wounding | response to mechanical stimulus | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of protein catabolic process | positive regulation of cell death | response to vitamin | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | regulation of phosphate metabolic process | positive regulation of TRAIL-activated apoptotic signaling pathway | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | response to organic cyclic compound | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | regulation of endopeptidase activity | developmental process | response to organonitrogen compound | negative regulation of hydrolase activity | central nervous system development | cellular response to organic substance | regulation of cell death | aging | tissue regeneration | positive regulation of apoptotic signaling pathway | positive regulation of signaling | regulation of signaling | negative regulation of endopeptidase activity | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
extracellular matrix | basement membrane | cell | cytoplasm | collagen-containing extracellular matrix | extracellular region | extracellular space | intracellular
