QuickView for TNF-R55;jsessionid=B06139021A823CEF84DFF5C295EF8075;jsessionid=B983C73F7D313B83F35BB0BC2F995721 (gene)

Gene Symbol:

Tnfrsf1a Mus musculus

Full name:

tumor necrosis factor receptor superfamily, member 1a

Synonyms:

CD120a, FPF, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNF-alphaR1, TNFAR, TNFR60, TNFRI, TNFRp55, TNFalpha-R1, Tnfr-2, Tnfr1, p55, p55-R, tumor necrosis factor receptor superfamily member 1A, TNF receptor alpha chain, TNF-RI, TNF-alpha-R1, TNFR-I, p60, tumor necrosis factor receptor 1, tumor necrosis factor receptor type I

Genomic Location:

Chr 6: 125299773-125312503

Description:

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor...

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This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

P300_01 ,  NRF2_01 ,  NFAT_Q6 ,  PTF1BETA_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  GGGAGGRR_MAZ_Q6 ,  TGGAAA_NFAT_Q4_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-29

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