QuickView for TOLL;jsessionid=618083722A248723A91A9042D518EE14;jsessionid=577E9A148951D7018957D0DC5AE358B9 (gene)
- Gene Symbol:
- Tlr4
Rattus norvegicus - Full name:
- toll-like receptor 4
- Synonyms:
- toll-like receptor 4, toll4
- Genomic Location:
- Chr 5: 83564100-83577735
- Description:
-
receptor that functions as the major upstream sensor for hemorrhagic shock and lipopolysaccharide
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , Macaca mulatta , Bos taurus , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
phosphatidylinositol 3-kinase binding | transmembrane signaling receptor activity | lipid binding | signaling receptor binding | carbohydrate derivative binding | signaling receptor activity | identical protein binding | protein heterodimerization activity | signaling pattern recognition receptor activity | protein binding | lipopolysaccharide receptor activity | protein dimerization activity | lipopolysaccharide binding
GO Biological Process
positive regulation of immune response | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | positive regulation of macrophage cytokine production | multicellular organismal movement | regulation of interleukin-1 beta production | adaptive immune response | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | detection of stimulus | response to cytokine | regulation of cellular response to oxidative stress | leukotriene metabolic process | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of B cell activation | immune response-regulating signaling pathway | response to lipopolysaccharide | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | response to isoquinoline alkaloid | positive regulation of DNA-binding transcription factor activity | interleukin-1 secretion | regulation of programmed cell death | negative regulation of interleukin-23 production | positive regulation of peptidyl-tyrosine phosphorylation | defense response to other organism | establishment of localization | regulation of immune system process | response to hormone | regulation of nitric oxide biosynthetic process | astrocyte development | negative regulation of cellular process | regulation of MAP kinase activity | epithelial structure maintenance | positive regulation of lymphocyte activation | regulation of interferon-beta biosynthetic process | cell differentiation | detection of mechanical stimulus involved in sensory perception | defense response | nervous system development | response to drug | negative regulation of protein phosphorylation | neurogenesis | positive regulation of interleukin-1 beta secretion | positive regulation of phosphate metabolic process | positive regulation of protein secretion | response to antibiotic | sensory perception of mechanical stimulus | tissue homeostasis | defense response to Gram-negative bacterium | regulation of neuron death | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | production of molecular mediator involved in inflammatory response | secretion | toll-like receptor signaling pathway | response to morphine | musculoskeletal movement | regulation of cytokine biosynthetic process | localization | protein transport | negative regulation of signaling | positive regulation of immune effector process | positive regulation of blood coagulation | positive regulation of reactive oxygen species metabolic process | response to progesterone | I-kappaB phosphorylation | positive regulation of macrophage activation | positive regulation of protein kinase activity | macromolecule localization | regulation of response to cytokine stimulus | response to hypoxia | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | regulation of binding | regulation of neurological system process | cellular response to oxidised low-density lipoprotein particle stimulus | anatomical structure homeostasis | regulation of interferon-beta production | cellular response to retinoic acid | regulation of platelet activation | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | positive regulation of stress-activated MAPK cascade | regulation of protein complex assembly | cellular response to molecule of bacterial origin | positive regulation of NLRP3 inflammasome complex assembly | positive regulation of interferon-gamma production | negative regulation of tumor necrosis factor production | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular response to interferon-gamma | positive regulation of tumor necrosis factor production | regulation of peptide secretion | regulation of type I interferon production | positive regulation of stress-activated protein kinase signaling cascade | muscle contraction | response to stimulus | positive regulation of interleukin-1 beta production | interleukin-1 beta secretion | positive regulation of NIK/NF-kappaB signaling | cellular response to mechanical stimulus | positive regulation of innate immune response | regulation of peptidyl-tyrosine phosphorylation | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | mononuclear cell proliferation | interleukin-1 beta production | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of cell proliferation | multicellular organismal homeostasis | negative regulation of interferon-gamma production | response to peptide | positive regulation of B cell proliferation | sensory perception of temperature stimulus | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | activation of innate immune response | secretion by cell | response to alcohol | positive regulation of cytokine secretion | response to temperature stimulus | response to molecule of bacterial origin | immune response-activating signal transduction | detection of lipopolysaccharide | regulation of DNA binding | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | regulation of wound healing | protein modification process | regulation of peptide transport | positive regulation of response to oxidative stress | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | activation of protein kinase activity | detection of temperature stimulus involved in sensory perception | response to ethanol | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of cellular response to stress | detection of abiotic stimulus | regulation of neurotransmitter levels | positive regulation of response to cytokine stimulus | response to nitrogen compound | positive regulation of reactive oxygen species biosynthetic process | regulation of NLRP3 inflammasome complex assembly | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | detection of molecule of bacterial origin | response to oxygen levels | positive regulation of response to wounding | nitrogen compound metabolic process | regulation of signal transduction | detection of chemical stimulus | pattern recognition receptor signaling pathway | regulation of interleukin-8 biosynthetic process | negative regulation of phosphate metabolic process | negative regulation of interleukin-6 production | multicellular organism development | response to activity | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | response to fatty acid | leukocyte mediated immunity | maintenance of gastrointestinal epithelium | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of sensory perception of pain | detection of mechanical stimulus involved in sensory perception of pain | regulation of gene expression | positive regulation of secretion | organic substance transport | response to ketone | response to lipid | nervous system process | cellular response to peptide | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of cellular response to oxidative stress | digestive system process | regulation of lymphocyte activation | response to ammonium ion | regulation of blood coagulation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | small molecule metabolic process | positive regulation of interleukin-12 production | peptide transport | positive regulation of intracellular signal transduction | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | positive regulation of protein complex assembly | response to corticosteroid | regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | regulation of transcription by RNA polymerase II | positive regulation of cytokine production involved in inflammatory response | negative regulation of interleukin-17 production | response to oxidative stress | cellular response to cytokine stimulus | B cell activation | cell proliferation | regulation of cytokine production involved in inflammatory response | leukocyte proliferation | sensory perception of pain | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | glial cell differentiation | phosphorylation | positive regulation of interleukin-1 secretion | response to transition metal nanoparticle | positive regulation of neuron death | positive regulation of chemokine production | regulation of interleukin-23 production | response to toxic substance | detection of temperature stimulus involved in sensory perception of pain | microglial cell activation | response to xenobiotic stimulus | protein phosphorylation | regulation of tumor necrosis factor production | phosphate-containing compound metabolic process | B cell proliferation involved in immune response | regulation of macrophage activation | response to bacterium | intestinal epithelial structure maintenance | regulation of interleukin-1 production | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of platelet activation | positive regulation of interleukin-1 production | positive regulation of interferon-beta biosynthetic process | signaling pattern recognition receptor activity | inflammatory response | astrocyte differentiation | cell activation involved in immune response | cellular response to amyloid-beta | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | positive regulation of oxidative stress-induced cell death | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of B cell activation | positive regulation of transport | striated muscle contraction | response to retinoic acid | cellular response to lipoprotein particle stimulus | regulation of nucleotide-binding oligomerization domain containing signaling pathway | carboxylic acid metabolic process | lymphocyte activation | positive regulation of interferon-alpha production | positive regulation of molecular function | regulation of cytokine secretion | activation of MAPK activity | cytokine production | positive regulation of myeloid leukocyte cytokine production involved in immune response | activation of immune response | protein metabolic process | regulation of establishment of protein localization | positive regulation of MHC class II biosynthetic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | lipopolysaccharide receptor activity | MyD88-independent toll-like receptor signaling pathway | regulation of kinase activity | response to mechanical stimulus | detection of stimulus involved in sensory perception | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular response to lipoteichoic acid | response to insulin | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cytokine secretion | regulation of interleukin-1 beta secretion | positive regulation of interleukin-12 biosynthetic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | positive regulation of coagulation | positive regulation of cytokine production involved in immune response | amide transport | regulation of secretion | positive regulation of cell death | toll-like receptor 4 signaling pathway | positive regulation of interleukin-6 production | macrophage activation | immune response | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of tumor necrosis factor biosynthetic process | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of tumor necrosis factor secretion | regulation of phosphate metabolic process | positive regulation of wound healing | response to alkaloid | regulation of dendritic cell cytokine production | positive regulation of binding | detection of mechanical stimulus | nitric oxide production involved in inflammatory response | establishment of protein localization | response to interferon-gamma | positive regulation of cytokine production | regulation of JNK cascade | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | negative regulation of protein metabolic process | sensory perception | icosanoid metabolic process | lymphocyte proliferation | regulation of response to wounding | regulation of stress-activated MAPK cascade | regulation of cell communication | positive regulation of interleukin-10 production | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | response to amyloid-beta | regulation of transcription, DNA-templated | glial cell development | response to organic cyclic compound | cell development | skeletal muscle contraction | positive regulation of DNA binding | I-kappaB kinase/NF-kappaB signaling | positive regulation of cellular response to macrophage colony-stimulating factor stimulus | protein localization | organic acid metabolic process | B cell activation involved in immune response | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | B cell mediated immunity | positive regulation of tumor necrosis factor biosynthetic process | positive regulation of oxidative stress-induced neuron death | detection of biotic stimulus | developmental process | cellular protein modification process | detection of temperature stimulus | B cell proliferation | digestion | regulation of chemokine production | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | regulation of B cell proliferation | innate immune response | MyD88-dependent toll-like receptor signaling pathway | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | regulation of interleukin-12 biosynthetic process | positive regulation of nitric oxide biosynthetic process | central nervous system development | response to anesthetic | positive regulation of metabolic process | positive regulation of interleukin-8 biosynthetic process | regulation of interferon-gamma production | immunoglobulin mediated immune response | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | protein secretion | positive regulation of type I interferon production | response to steroid hormone | regulation of interleukin-6 production | regulation of inflammatory response | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | muscle system process | response to other organism | response to gold nanoparticle | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of nitric-oxide synthase biosynthetic process | positive regulation of gene expression | response to glucocorticoid | interferon-gamma production | positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | cellular response to lipopolysaccharide | macromolecule metabolic process | positive regulation of interferon-beta production | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | protein-containing complex | endomembrane system | plasma membrane | membrane raft | vesicle | perinuclear region of cytoplasm | integral component of plasma membrane | endosome | membrane-bounded organelle | organelle | cell periphery | early endosome | intracellular vesicle | cell surface | lipopolysaccharide receptor complex | intracellular | membrane | intrinsic component of plasma membrane
