QuickView for TOM34;jsessionid=6FF79935C84B27EDFF97C2B585048E84;jsessionid=9C08FEE47FADE67A118EF9458CF6DB22;jsessionid=899B3062B3D1B49E46B4B4F34A65C0A6;jsessionid=0C5BB7AD7551EEDC39F70BBAE65F0C8B (gene)

Gene Symbol:

UNC45B Homo sapiens

Full name:

unc-45 myosin chaperone B

Synonyms:

CMYA4, CTRCT43, SMUNC45, UNC-45B, UNC45, protein unc-45 homolog B, cardiomyopathy associated 4, striated muscle UNC45, unc-45 homolog B

Genomic Location:

Chr 17: 30498949-30540477

Description:

This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protei...

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This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  RTAAACA_FREAC2_01 ,  GGGATGC_MIR3245P ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  TTCNRGNNNNTTC_HSF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  E2A_Q2 ,  ATGCTGG_MIR338 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  MYOD_Q6 ,  MYOGENIN_Q6 ,  GATA1_05 ,  PAX_Q6 ,  CAGCTG_AP4_Q5 ,  SRF_C ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

17q12

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