QuickView for TOP2A;jsessionid=F31FED6080A74ABBA9DB566F5F4EB4EC;jsessionid=43125B61D96E5CA59BEC159720A1EF0A (gene)
- Gene Symbol:
- TOP2
Saccharomyces cerevisiae - Full name:
- Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
- Synonyms:
- Top2, TOP2, TOP2, TOR3, TRF3, YNL088W
- Genomic Location:
- Chr XIV: 457706-461992
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cation binding | isomerase activity | nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | DNA binding | purine nucleotide binding | DNA topoisomerase type II (ATP-hydrolyzing) activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | DNA topoisomerase II activity | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | DNA-dependent ATPase activity | drug binding | metal ion binding | heterocyclic compound binding | DNA topoisomerase activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
replication fork progression beyond termination site | negative regulation of cellular process | regulation of DNA replication | cellular process | chromatin organization | mitotic DNA integrity checkpoint | resolution of meiotic recombination intermediates | regulation of cell cycle | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | regulation of DNA recombination | chromosome segregation | reproduction | cellular nitrogen compound metabolic process | cellular biosynthetic process | DNA recombination | meiotic chromosome segregation | meiotic chromosome separation | nitrogen compound metabolic process | reproductive process | sister chromatid segregation | cell cycle | regulation of nitrogen compound metabolic process | biosynthetic process | regulation of DNA-dependent DNA replication | nuclear chromosome segregation | DNA topological change | DNA strand elongation | regulation of cellular metabolic process | chromatin remodeling | regulation of mitotic cell cycle | DNA metabolic process | reciprocal meiotic recombination | chromatin assembly or disassembly | mitotic cell cycle | nuclear division | metabolic process | regulation of mitotic recombination | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | organic substance metabolic process | meiosis I | negative regulation of cell cycle | meiotic cell cycle | cellular macromolecule biosynthetic process | homologous recombination | organelle organization | DNA strand elongation involved in DNA replication | DNA conformation change | heterocycle metabolic process | chromosome organization | chromatin remodeling at centromere | mitotic cell cycle checkpoint | cellular metabolic process | chromosome separation | cell cycle checkpoint | DNA replication | macromolecule metabolic process
GO Cellular Component
condensed nuclear chromosome | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | synaptonemal complex | cytoplasm | intracellular organelle | DNA replication termination region | nuclear chromosome | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular | condensed chromosome
