QuickView for TR2L;jsessionid=B27EB6C1849309FD8F81A3A0026E2DA9;jsessionid=28CFB5E4B2014B3FC30A8DD7EFBCE7EE;jsessionid=1B851AEAC010A2C6F27D34DDEF0BA983 (gene)

Gene Symbol:

APBB2 Homo sapiens

Full name:

amyloid beta precursor protein binding family B member 2

Synonyms:

FE65L, FE65L1, amyloid-beta A4 precursor protein-binding family B member 2, amyloid beta A4 precursor protein-binding family B member 2, Fe65-like 1, protein Fe65-like 1

Genomic Location:

Chr 4: 40510996-40911245

Description:

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease...

View Full Description

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  SMAD3_Q6 ,  GCANCTGNY_MYOD_Q6 ,  CAGTGTT_MIR141_MIR200A ,  CTTTGA_LEF1_Q2 ,  E2A_Q2 ,  TGCCTTA_MIR124A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ATATGCA_MIR448 ,  AAAYRNCTG_UNKNOWN ,  STAT5A_04 ,  CTGCAGY_UNKNOWN ,  TGCTTTG_MIR330 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  CACTTTG_MIR520G_MIR520H

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-31

Cytogenetic Map:

4p14-p13

search → result