QuickView for TRKB;jsessionid=BEE68A6FE0CD85BEF242000C9EF7FEEF;jsessionid=6B6F129CDD53D34A0C1FDB2B7BE94EEB (gene)

GO Molecular Function

neurotrophin binding | transmembrane receptor protein tyrosine kinase activity | voltage-gated ion channel activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | ribonucleotide binding | transmembrane transporter activity | nucleotide binding | ion gated channel activity | carbohydrate derivative binding | growth factor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | brain-derived neurotrophic factor binding | ephrin receptor activity | signaling receptor activity | purine nucleotide binding | transporter activity | identical protein binding | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | GPI-linked ephrin receptor activity | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein homodimerization activity | brain-derived neurotrophic factor-activated receptor activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | neurotrophin receptor activity | purine ribonucleotide binding | voltage-gated channel activity | adenyl ribonucleotide binding | channel activity | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | brain development | cell morphogenesis | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | regulation of synapse assembly | regulation of cell development | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | eye development | establishment of localization | negative regulation of neuron death | neuron migration | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | nervous system development | cell part morphogenesis | positive regulation of axonogenesis | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | voltage-gated ion channel activity | positive regulation of collateral sprouting | generation of neurons | blood vessel morphogenesis | regulation of neuron death | cellular process | secretion | peripheral nervous system development | localization | cell projection morphogenesis | positive regulation of synaptic transmission | passive transmembrane transporter activity | negative regulation of signaling | developmental growth | positive regulation of peptidyl-serine phosphorylation | neuron development | central nervous system neuron differentiation | negative regulation of anoikis | dicarboxylic acid transport | anion transport | learning | negative regulation of apoptotic process | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | retinal rod cell development | regulation of cell differentiation | regulation of protein kinase B signaling | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | gliogenesis | transmembrane transporter activity | response to nerve growth factor | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | ephrin receptor signaling pathway | cellular component organization | head development | response to stimulus | ion gated channel activity | vasculature development | cell morphogenesis involved in neuron differentiation | acid secretion | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | regulation of cell proliferation | tube morphogenesis | circadian rhythm | regulation of dendrite extension | secretion by cell | cardiovascular system development | rhythmic process | regulation of cellular component size | regulation of anoikis | protein modification process | regulation of synapse structure or activity | modulation of chemical synaptic transmission | macromolecule modification | cell-cell signaling | eye photoreceptor cell differentiation | blood vessel development | locomotion | response to nitrogen compound | negative regulation of neuron apoptotic process | central nervous system neuron development | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of neuron projection development | multicellular organism development | cell migration | regulation of MAPK cascade | phosphorus metabolic process | response to amino acid | learning or memory | regulation of axonogenesis | regulation of catalytic activity | cellular response to nerve growth factor stimulus | regulation of phosphorylation | ion transmembrane transport | mechanoreceptor differentiation | telencephalon development | regulation of neuron differentiation | regulation of gene expression | axon development | organic substance transport | nervous system process | synaptic signaling | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | neuromuscular junction development | animal organ morphogenesis | regulation of synapse organization | ephrin receptor activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | organic acid transport | synapse organization | ion transmembrane transporter activity | axonogenesis | positive regulation of cell differentiation | cognition | regulation of cellular protein metabolic process | neurotrophin signaling pathway | glial cell differentiation | organic anion transport | phosphorylation | regulation of GTPase activity | cellular response to amino acid stimulus | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | sensory organ development | cell communication | regulation of cellular metabolic process | eye morphogenesis | regulation of neuron apoptotic process | regulation of protein metabolic process | positive regulation of signal transduction | vasculogenesis | positive regulation of cell proliferation | regulation of protein phosphorylation | GPI-linked ephrin receptor activity | brain-derived neurotrophic factor receptor signaling pathway | positive regulation of synapse assembly | eye photoreceptor cell development | cerebral cortex development | amino acid transport | protein tyrosine kinase activity | neuron differentiation | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | retina development in camera-type eye | brain-derived neurotrophic factor-activated receptor activity | regulation of intracellular signal transduction | anatomical structure development | developmental growth involved in morphogenesis | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | trans-synaptic signaling by neuropeptide, modulating synaptic transmission | negative regulation of programmed cell death | peripheral nervous system neuron development | collateral sprouting | oligodendrocyte differentiation | behavior | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | animal organ development | forebrain development | pallium development | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | neurotrophin receptor activity | positive regulation of MAPK cascade | camera-type eye development | regulation of peptidyl-serine phosphorylation | regulation of collateral sprouting | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | positive regulation of developmental growth | signaling | feeding behavior | positive regulation of growth | cell development | regulation of developmental growth | positive regulation of phosphorylation | voltage-gated channel activity | cellular protein metabolic process | regulation of cell size | carboxylic acid transport | anatomical structure morphogenesis | channel activity | glutamate secretion | regulation of nervous system development | regulation of developmental process | kinase activity | developmental process | regulation of cell growth | cellular protein modification process | tube development | developmental cell growth | response to organonitrogen compound | photoreceptor cell development | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of synaptic plasticity | positive regulation of neuron differentiation | ion transport | regulation of cell projection organization | cellular metabolic process | long-term synaptic potentiation | photoreceptor cell differentiation | cellular response to organic substance | regulation of cell death | peripheral nervous system neuron differentiation | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | circulatory system development | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

dendritic spine | integral component of membrane | dendrite | synapse | neuron projection | somatodendritic compartment | organelle membrane | cytoplasmic vesicle | cell | distal axon | intrinsic component of membrane | synaptic membrane | terminal bouton | cytoplasm | intracellular organelle | receptor complex | dendritic tree | presynapse | endosome membrane | protein-containing complex | cell projection | postsynaptic membrane | endomembrane system | neuron spine | postsynapse | plasma membrane | vesicle | perinuclear region of cytoplasm | postsynaptic density | asymmetric synapse | integral component of plasma membrane | endosome | membrane-bounded organelle | organelle | postsynaptic specialization | axon terminus | cell periphery | axon | early endosome | neuron projection terminus | cytosol | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane

PATHWAYS

PID_SHP2_PATHWAY | PID_AJDISS_2PATHWAY | PID_TRKR_PATHWAY | REACTOME_SIGNALLING_BY_NGF | REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE

PROTEIN FAMILY

Leucine-rich repeat N-terminal domain | Cysteine-rich flanking region, C-terminal | Protein kinase domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | Leucine-rich repeat | Tyrosine-protein kinase, receptor class II, conserved site | Immunoglobulin subtype 2 | Immunoglobulin subtype | Immunoglobulin-like domain | Tyrosine-protein kinase, active site | Protein kinase-like domain superfamily | Immunoglobulin I-set | Immunoglobulin-like fold | Protein kinase, ATP binding site | Tyrosine-protein kinase, neurotrophic receptor, type 2 | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, neurotrophic receptor | Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain | Leucine-rich repeat domain superfamily | Immunoglobulin-like domain superfamily