QuickView for TYMS;jsessionid=32606BCA4BF7C0F200A3639139A3DFB4;jsessionid=7A91D97FBAC43506FF1FB37C242420EB (gene)
- Gene Symbol:
- Tyms
Mus musculus - Full name:
- thymidylate synthase
- Synonyms:
- Ts, thymidylate synthase, Tsase
- Genomic Location:
- Chr 5: 30385367-30400121
- Description:
-
This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for cancer chemotherapeutic agents. The majority of tra...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
GO Molecular Function
cofactor binding | modified amino acid binding | carboxylic acid binding | nucleic acid binding | mRNA binding | vitamin binding | nucleotide binding | thymidylate synthase activity | catalytic activity | translation regulator activity, nucleic acid binding | sequence-specific mRNA binding | anion binding | folic acid binding | amide binding | identical protein binding | 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | translation repressor activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | translation regulator activity | translation repressor activity, mRNA regulatory element binding | protein dimerization activity | transferase activity | drug binding | methyltransferase activity | organic acid binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
deoxyribonucleoside monophosphate biosynthetic process | negative regulation of cellular process | tetrahydrofolate metabolic process | cellular process | nucleotide metabolic process | negative regulation of cellular metabolic process | deoxyribonucleotide biosynthetic process | regulation of cellular process | regulation of metabolic process | one-carbon metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | folic acid-containing compound metabolic process | pyrimidine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | negative regulation of metabolic process | cofactor metabolic process | cellular biosynthetic process | pteridine-containing compound metabolic process | thymidylate synthase activity | nucleotide biosynthetic process | translation regulator activity, nucleic acid binding | dUMP metabolic process | nitrogen compound metabolic process | phosphorus metabolic process | regulation of gene expression | methylation | organophosphate metabolic process | deoxyribonucleotide metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | cellular amide metabolic process | pyrimidine nucleotide biosynthetic process | nucleobase-containing small molecule metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | translation repressor activity | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of protein metabolic process | carboxylic acid metabolic process | dTMP biosynthetic process | translation regulator activity | translation repressor activity, mRNA regulatory element binding | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | tetrahydrofolate interconversion | negative regulation of translation | negative regulation of protein metabolic process | organic acid metabolic process | methyltransferase activity | carbohydrate derivative metabolic process | cellular modified amino acid metabolic process | heterocycle metabolic process | cellular metabolic process | regulation of translation | nucleoside monophosphate biosynthetic process
GO Cellular Component
mitochondrial matrix | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | intracellular | membrane
