QuickView for TYMS;jsessionid=32606BCA4BF7C0F200A3639139A3DFB4;jsessionid=5BEC0136509BEA6A63174719240A3E3E (gene)
- Gene Symbol:
- Tyms
Rattus norvegicus - Full name:
- thymidylate synthetase
- Synonyms:
- thymidylate synthase, TS, TSase
- Genomic Location:
- Chr 9: 112605357-112617706
- Description:
-
catalyzes the reductive methylation of dUMP to dTMP using CH2H4PteGlu as both the methyl donor and reductant
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
GO Molecular Function
cofactor binding | modified amino acid binding | carboxylic acid binding | nucleic acid binding | mRNA binding | vitamin binding | nucleotide binding | thymidylate synthase activity | catalytic activity | translation regulator activity, nucleic acid binding | sequence-specific mRNA binding | anion binding | folic acid binding | amide binding | identical protein binding | 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | translation repressor activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | translation regulator activity | translation repressor activity, mRNA regulatory element binding | protein dimerization activity | transferase activity | drug binding | methyltransferase activity | organic acid binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
response to extracellular stimulus | response to nutrient levels | response to cytokine | deoxyribonucleoside monophosphate biosynthetic process | response to hormone | negative regulation of cellular process | cell differentiation | deoxyribonucleoside triphosphate metabolic process | response to drug | immortalization of host cell | response to antibiotic | tetrahydrofolate metabolic process | response to folic acid | response to organophosphorus | cellular process | cell maturation | nucleotide metabolic process | developmental growth | response to progesterone | nucleoside triphosphate metabolic process | negative regulation of cellular metabolic process | tissue development | deoxyribonucleotide biosynthetic process | interspecies interaction between organisms | regeneration | regulation of cellular process | regulation of metabolic process | one-carbon metabolic process | hepaticobiliary system development | organic cyclic compound metabolic process | epithelium development | cellular aromatic compound metabolic process | folic acid-containing compound metabolic process | response to stimulus | pyrimidine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | epithelial cell development | circadian rhythm | response to alcohol | rhythmic process | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | negative regulation of metabolic process | cofactor metabolic process | cartilage development | intestinal epithelial cell development | cellular biosynthetic process | pteridine-containing compound metabolic process | thymidylate synthase activity | nucleotide biosynthetic process | translation regulator activity, nucleic acid binding | response to ethanol | response to nitrogen compound | dUMP metabolic process | system development | nitrogen compound metabolic process | transformation of host cell by virus | multicellular organism development | phosphorus metabolic process | regulation of gene expression | methylation | response to ketone | response to lipid | organophosphate metabolic process | modification of morphology or physiology of other organism | deoxyribonucleotide metabolic process | liver development | regulation of nitrogen compound metabolic process | small molecule metabolic process | response to corticosteroid | cellular amide metabolic process | response to nutrient | pyrimidine nucleotide biosynthetic process | nucleobase-containing small molecule metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | immortalization of host cell by virus | digestive tract development | response to vitamin A | response to toxic substance | translation repressor activity | nucleoside triphosphate biosynthetic process | phosphate-containing compound metabolic process | epithelial cell maturation | regulation of cellular metabolic process | liver regeneration | regulation of protein metabolic process | viral process | intestinal epithelial cell differentiation | drug metabolic process | carboxylic acid metabolic process | dTMP biosynthetic process | response to organic substance | gland development | translation regulator activity | digestive system development | translation repressor activity, mRNA regulatory element binding | uracil metabolic process | anatomical structure development | metabolic process | developmental maturation | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | tetrahydrofolate interconversion | negative regulation of translation | negative regulation of protein metabolic process | dTTP biosynthetic process | pyrimidine nucleobase metabolic process | response to organic cyclic compound | cell development | organic acid metabolic process | methyltransferase activity | developmental process | deoxyribonucleoside triphosphate biosynthetic process | columnar/cuboidal epithelial cell development | tube development | carbohydrate derivative metabolic process | modulation by virus of host morphology or physiology | response to organonitrogen compound | epithelial cell differentiation | cellular modified amino acid metabolic process | heterocycle metabolic process | intestinal epithelial cell maturation | skeletal system development | cellular metabolic process | response to steroid hormone | regulation of translation | aging | pyrimidine deoxyribonucleoside triphosphate biosynthetic process | nucleoside monophosphate biosynthetic process | animal organ regeneration | response to glucocorticoid | multicellular organismal process
GO Cellular Component
mitochondrial matrix | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | intracellular | membrane
