QuickView for Tgase1;jsessionid=ADCD04A9A73600375E0B869440E0B31D;jsessionid=CCB007F58B1EE88EA67499B1FC53BD3E;jsessionid=7623C32EE4291735F79D3579B75E1C0E;jsessionid=BCCF22022F8A096E661C26A64AF739C8 (gene)

Gene Symbol:

TGM1 Homo sapiens

Full name:

transglutaminase 1

Synonyms:

ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK, protein-glutamine gamma-glutamyltransferase K, K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase, TG(K), TGase K, TGase-1, epidermal TGase, transglutaminase 1 isoform, transglutaminase K, transglutaminase, keratinocyte

Genomic Location:

Chr 14: 23788160-23802256

Description:

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 ...

View Full Description

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  GCANCTGNY_MYOD_Q6 ,  CTTTGA_LEF1_Q2 ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  CAGGTG_E12_Q6 ,  MYOD_Q6 ,  TGACATY_UNKNOWN

Cytogenetic Map:

14q12

search → result