QuickView for Tns1;jsessionid=ADD17D090B2260497812E97C2E874C12;jsessionid=D72CC756A9C3F3495A83EA8197CC36BA;jsessionid=3F62287A8ACA9D20A78B33B99EC76C0C;jsessionid=7DBDA9B4EB876B071CD16D1B906967A8 (gene)

Gene Symbol:

TNS1 Homo sapiens

Full name:

tensin 1

Synonyms:

MST091, MST122, MST127, MSTP091, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, tensin-1, Matrix-remodelling-associated protein 6, matrix-remodelling associated 6, protein phosphatase 1, regulatory subunit 155

Genomic Location:

Chr 2: 218372757-218517041

Description:

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternati...

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The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  HNF1_01 ,  PPARA_01 ,  HNF1_C ,  SREBP1_Q6 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  GGATTA_PITX2_Q2 ,  RP58_01 ,  CAGGTG_E12_Q6 ,  PXR_Q2 ,  YCATTAA_UNKNOWN ,  AAAYRNCTG_UNKNOWN ,  ARGGGTTAA_UNKNOWN ,  CAGCTG_AP4_Q5 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

2q35

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