QuickView for Tpm-2;jsessionid=CE67D50936C7832BA659B5B0F1021DF1;jsessionid=D46352AA38BDC4625FE4FAAD5FEE62FB;jsessionid=22133B46935C9A4286A3AA1CEBE7641C;jsessionid=5E6134C03CA45A7B90686B89F21072DB;jsessionid=E7868090EEB391C8CACF1A409202B72C;jsessionid=2B24804A313E4590403905CE0BC203BB;jsessionid=EE2C19E132350E340469B85360746C3B (gene)

Gene Symbol:

Tpm2 Mus musculus

Full name:

tropomyosin 2, beta

Synonyms:

Tpm-2, Trop-2, tropomyosin beta chain

Genomic Location:

Chr 4: 43527584-43536260

Description:

This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and di...

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This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MEF2_01 ,  NMYC_01 ,  E47_02 ,  CEBPB_01 ,  HSF1_01 ,  HSF2_01 ,  COUP_01 ,  SRF_Q6 ,  MEF2_02 ,  MEF2_03 ,  NKX25_02 ,  AMEF2_Q6 ,  HMEF2_Q6 ,  RSRFC4_Q2 ,  MEIS1AHOXA9_01 ,  MEIS1BHOXA9_01 ,  ZIC1_01 ,  TBP_01 ,  GCM_Q2 ,  PPAR_DR1_Q2 ,  COUP_DR1_Q6 ,  TTF1_Q6 ,  SRF_Q4 ,  SRF_Q5_01 ,  MEF2_Q6_01 ,  YCATTAA_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  TGANTCA_AP1_C ,  CAGCTG_AP4_Q5 ,  TGACCTY_ERR1_Q2 ,  RYTTCCTG_ETS2_B ,  RGAANNTTC_HSF1_01 ,  GGGAGGRR_MAZ_Q6 ,  TGACAGNY_MEIS1_01 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  TGGAAA_NFAT_Q4_01 ,  GGATTA_PITX2_Q2 ,  RGAGGAARY_PU1_Q6 ,  CTAWWWATA_RSRFC4_Q2 ,  GGGCGGR_SP1_Q6 ,  CCAWWNAAGG_SRF_Q4 ,  TATAAA_TATA_01

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