QuickView for Trxrd2;jsessionid=2FFFB5DAB79F582B6FD77328787EBD68;jsessionid=6E596FE2770510AA56965877BCE447DB;jsessionid=19ECD53749E3642A9EDB9A206DDD53AF;jsessionid=DC296A072C54A9C66E47FBFB982C52B8 (gene)

Gene Symbol:

TXNRD2 Homo sapiens

Full name:

thioredoxin reductase 2

Synonyms:

GCCD5, SELZ, TR, TR-BETA, TR3, TRXR2, thioredoxin reductase 2, mitochondrial, selenoprotein Z, thioredoxin reductase 3, thioredoxin reductase TR3, thioredoxin reductase beta

Genomic Location:

Chr 22: 18243040-18309359

Description:

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox...

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The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Cytogenetic Map:

22q11.21

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