QuickView for VKORC1;jsessionid=008AB1C08C464A1FF881CB2ECF11C865;jsessionid=2F2F6C68BC326AA37712C5D08923D18C (gene)

Gene Symbol:

Vkorc1 Mus musculus

Full name:

vitamin K epoxide reductase complex, subunit 1

Synonyms:

D7Wsu86e, vitamin K epoxide reductase complex subunit 1, phylloquinone epoxide reductase, vitamin K 2,3-epoxide reductase complex subunit 1, vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive)

Genomic Location:

Chr 7: 135036577-135039131

Description:

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatica...

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Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACTAYRNNNCCCR_UNKNOWN ,  TCCCRNNRTGC_UNKNOWN

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