QuickView for VPS4;jsessionid=0FE4A174A2C4A1460E969ABB0D674258;jsessionid=553086724DB98E28CCBBEDC9FEFCF4FE (gene)

Gene Symbol:

VPS4B Homo sapiens

Full name:

vacuolar protein sorting 4 homolog B

Synonyms:

MIG1, SKD1, SKD1B, VPS4-2, vacuolar protein sorting-associated protein 4B, cell migration-inducing 1, cell migration-inducing gene 1 protein, suppressor of K(+) transport growth defect 1, suppressor of K+ transport defect 1, vacuolar protein sorting 4B

Genomic Location:

Chr 18: 59207403-59240732

Description:

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Sk...

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The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  TTTGCAC_MIR19A_MIR19B ,  CREB_Q3 ,  CTCAGGG_MIR125B_MIR125A ,  GGGCGGR_SP1_Q6 ,  GTGCCTT_MIR506 ,  ELK1_01 ,  ATAACCT_MIR154

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

18q21.33

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