QuickView for Zap70;jsessionid=4546AB00905DCA769D0D44C90394AFEE;jsessionid=B74C3161A418CE56ABBB4F83BA943E1A (gene)

Gene Symbol:

Zap70 Mus musculus

Full name:

zeta-chain (TCR) associated protein kinase

Synonyms:

Srk, ZAP-70, mrtle, mur, tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, syk-related tyrosine kinase

Genomic Location:

Chr 1: 36818706-36839661

Description:

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lack...

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This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT1_02 ,  STAT1_03

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