QuickView for acl;jsessionid=5413DCB73AF0264F1B3E64A044750076;jsessionid=77CA5A49A80506DD49121412EB992CAA (gene)
- Gene Symbol:
- ACLY
Homo sapiens - Full name:
- ATP citrate lyase
- Synonyms:
- ACL, ATPCL, CLATP, ATP-citrate synthase, ATP-citrate (pro-S-)-lyase, citrate cleavage enzyme
- Genomic Location:
- Chr 17: 37276705-37328798
- Description:
-
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and pho...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17q21.2
GO Molecular Function
cofactor binding | cation binding | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | transferase activity, transferring acyl groups | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity | ATP citrate synthase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
purine ribonucleotide metabolic process | exocytosis | neutrophil activation | sulfur compound metabolic process | establishment of localization | acetyl-CoA biosynthetic process | sterol metabolic process | cellular process | secretion | leukocyte degranulation | localization | dicarboxylic acid metabolic process | nucleotide metabolic process | ribose phosphate metabolic process | purine nucleotide biosynthetic process | ribonucleotide metabolic process | regulation of cellular process | leukocyte activation | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | steroid biosynthetic process | cellular lipid metabolic process | response to stimulus | purine nucleotide metabolic process | monocarboxylic acid metabolic process | neutrophil degranulation | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | alcohol metabolic process | acetyl-CoA metabolic process | secretion by cell | coenzyme A metabolic process | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cofactor metabolic process | cellular biosynthetic process | fatty-acyl-CoA biosynthetic process | nucleotide biosynthetic process | organic hydroxy compound metabolic process | nitrogen compound metabolic process | coenzyme biosynthetic process | antibiotic metabolic process | phosphorus metabolic process | acyl-CoA metabolic process | leukocyte mediated immunity | lipid metabolic process | organophosphate metabolic process | positive regulation of cellular metabolic process | sterol biosynthetic process | cofactor biosynthetic process | small molecule metabolic process | cellular amide metabolic process | vesicle-mediated transport | nucleobase-containing small molecule metabolic process | fatty acid biosynthetic process | biosynthetic process | cholesterol biosynthetic process | aromatic compound biosynthetic process | purine ribonucleotide biosynthetic process | regulated exocytosis | lipid biosynthetic process | phosphate-containing compound metabolic process | regulation of cellular metabolic process | oxaloacetate metabolic process | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | drug metabolic process | carboxylic acid metabolic process | tricarboxylic acid metabolic process | metabolic process | cholesterol metabolic process | citrate metabolic process | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | amide biosynthetic process | fatty acid metabolic process | cell activation | steroid metabolic process | ribose phosphate biosynthetic process | organic acid metabolic process | carbohydrate derivative metabolic process | neutrophil mediated immunity | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process
GO Cellular Component
secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | nuclear lumen | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | ficolin-1-rich granule lumen | protein-containing complex | secretory vesicle | endomembrane system | nucleoplasm | plasma membrane | vacuole | vesicle | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | citrate lyase complex | extracellular space | cell periphery | membrane-enclosed lumen | azurophil granule | secretory granule lumen | cytosol | intracellular vesicle | intracellular | membrane | vesicle lumen
