QuickView for caspase-3;jsessionid=668A472189A2ACE74BB528DE7DF9A76D;jsessionid=273238E1D37E49CE08FC89370B412BFB;jsessionid=7355EF94883D32B409A303D6A8935F5A (gene)
- Gene Symbol:
- Casp3
Mus musculus - Full name:
- caspase 3
- Synonyms:
- A830040C14Rik, AC-3, CASP-3, CC3, CPP-32, CPP32, Caspase-3, Lice, SCA-1, Yama, mldy, caspase-3, SREBP cleavage activity 1, apopain, caspase 3, apoptosis related cysteine protease, cysteine protease CPP32, protein Yama
- Genomic Location:
- Chr 8: 47702803-47724071
- Description:
-
This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this ge...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
enzyme activator activity | protein kinase regulator activity | protein serine/threonine kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | lipase activator activity | kinase regulator activity | protein kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic process | enzyme binding | protein-containing complex binding | aspartic-type peptidase activity | enzyme inhibitor activity | signaling receptor binding | hydrolase activity | cytokine receptor binding | cysteine-type peptidase activity | molecular function regulator | catalytic activity | cysteine-type endopeptidase activity involved in execution phase of apoptosis | death receptor binding | phospholipase A2 activator activity | cysteine-type endopeptidase activity | protein binding | aspartic-type endopeptidase activity | kinase inhibitor activity | phospholipase activator activity | endopeptidase activity | enzyme regulator activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | protease binding | tumor necrosis factor receptor superfamily binding | peptidase activity | cyclin-dependent protein serine/threonine kinase regulator activity
GO Biological Process
leukocyte homeostasis | negative regulation of leukocyte activation | negative regulation of phosphorylation | response to radiation | negative regulation of immune system process | response to endoplasmic reticulum stress | regulation of B cell activation | negative regulation of activated T cell proliferation | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | proteolysis | protein kinase regulator activity | regulation of programmed cell death | erythrocyte homeostasis | regulation of immune system process | myeloid cell differentiation | neuron death | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of leukocyte cell-cell adhesion | protein processing | cell differentiation | protein serine/threonine kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | nervous system development | negative regulation of B cell proliferation | response to drug | negative regulation of protein phosphorylation | neurogenesis | lipase activator activity | generation of neurons | response to antibiotic | sensory perception of mechanical stimulus | regulation of neuron death | cellular process | kinase regulator activity | protein kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic process | immune system development | negative regulation of apoptotic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | negative regulation of T cell proliferation | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | intrinsic apoptotic signaling pathway | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of mononuclear cell proliferation | aspartic-type peptidase activity | epithelium development | cellular response to organonitrogen compound | response to UV | response to stimulus | enzyme inhibitor activity | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | regulation of cell proliferation | response to glucose | execution phase of apoptosis | programmed cell death | cellular response to organic cyclic compound | negative regulation of metabolic process | hemopoiesis | cellular response to staurosporine | regulation of cell adhesion | cysteine-type peptidase activity | molecular function regulator | myeloid cell homeostasis | response to nitrogen compound | apoptotic process | response to light stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | cysteine-type endopeptidase activity involved in execution phase of apoptosis | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | learning or memory | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | cellular response to ammonium ion | regulation of T cell activation | regulation of activated T cell proliferation | cellular response to stress | nervous system process | negative regulation of cyclin-dependent protein serine/threonine kinase activity | regulation of lymphocyte activation | response to ammonium ion | glial cell apoptotic process | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | neuron apoptotic process | negative regulation of protein serine/threonine kinase activity | cellular response to alkaloid | response to oxidative stress | B cell homeostasis | cognition | epidermal cell differentiation | homeostasis of number of cells | phospholipase A2 activator activity | response to osmotic stress | regulation of cellular protein metabolic process | neurotrophin signaling pathway | positive regulation of neuron death | protein maturation | epidermis development | response to toxic substance | skin development | keratinocyte differentiation | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | lymphocyte homeostasis | negative regulation of cell activation | sensory perception of sound | regulation of protein metabolic process | heart development | homeostatic process | response to monosaccharide | regulation of protein phosphorylation | cysteine-type endopeptidase activity | apoptotic signaling pathway | negative regulation of B cell activation | positive regulation of molecular function | neuron differentiation | negative regulation of cyclin-dependent protein kinase activity | protein metabolic process | response to organic substance | neurotrophin TRK receptor signaling pathway | aspartic-type endopeptidase activity | kinase inhibitor activity | regulation of kinase activity | response to wounding | cellular response to osmotic stress | positive regulation of neuron apoptotic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | negative regulation of leukocyte proliferation | negative regulation of programmed cell death | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | behavior | positive regulation of cell death | organic substance metabolic process | cell death | animal organ development | response to reactive oxygen species | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | positive regulation of programmed cell death | regulation of phosphate metabolic process | response to alkaloid | intrinsic apoptotic signaling pathway in response to osmotic stress | T cell homeostasis | phospholipase activator activity | negative regulation of cell cycle | negative regulation of protein metabolic process | sensory perception | negative regulation of molecular function | signaling | response to organic cyclic compound | endopeptidase activity | regulation of T cell proliferation | enzyme regulator activity | developmental process | cyclin-dependent protein serine/threonine kinase inhibitor activity | erythrocyte differentiation | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of cell-cell adhesion | response to organonitrogen compound | epithelial cell differentiation | transmembrane receptor protein tyrosine kinase signaling pathway | negative regulation of lymphocyte proliferation | immune system process | hematopoietic or lymphoid organ development | peptidase activity | cellular response to organic substance | regulation of cell death | response to carbohydrate | negative regulation of cell death | circulatory system development | signal transduction | cellular response to growth factor stimulus | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | plasma membrane protein complex | cytoplasm | death-inducing signaling complex | intracellular organelle | membrane microdomain | protein-containing complex | plasma membrane | membrane raft | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane
