QuickView for cyclin E;jsessionid=AD3C7B9A9259D6D6D06FE747886EE65C (gene)

Gene Symbol:

CCNE1 Homo sapiens

Full name:

cyclin E1

Synonyms:

CCNE, pCCNE1, G1/S-specific cyclin-E1

Genomic Location:

Chr 19: 34994741-35007059

Description:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of ...

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  NFMUE1_Q6 ,  ZF5_01 ,  TACTTGA_MIR26A_MIR26B ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  GCTTGAA_MIR498 ,  CACCAGC_MIR138 ,  GGGCGGR_SP1_Q6 ,  LMO2COM_02 ,  CCAWNWWNNNGGC_UNKNOWN ,  GATA1_02 ,  YGCGYRCGC_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TGACCTTG_SF1_Q6 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

19q12

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