QuickView for dsirt2;jsessionid=F67158940E90BADC7CE22F60D85A06EB;jsessionid=56AEAE073337738970A1EEE1702E04ED (gene)
- Gene Symbol:
- sirt2
Danio rerio - Full name:
- sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
- Synonyms:
- wu:fb57d05, zgc:55966, zgc:77003
- Genomic Location:
- N/A
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , Saccharomyces cerevisiae , Schizosaccharomyces pombe , Pan troglodytes , Bos taurus , Gallus gallus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cofactor binding | tubulin deacetylase activity | histone deacetylase activity (H4-K16 specific) | cation binding | nucleotide binding | coenzyme binding | hydrolase activity | protein deacetylase activity | NAD+ binding | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | anion binding | histone deacetylase activity | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | zinc ion binding | NAD-dependent histone deacetylase activity (H4-K16 specific) | NAD binding | transition metal ion binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
response to extracellular stimulus | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | response to nutrient levels | regulation of neurogenesis | positive regulation of apoptotic process | regulation of cell development | regulation of programmed cell death | regulation of autophagy | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | tubulin deacetylase activity | positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia | nervous system development | positive regulation of protein catabolic process | histone deacetylation | neurogenesis | generation of neurons | histone deacetylase activity (H4-K16 specific) | positive regulation of cellular biosynthetic process | cellular process | tubulin deacetylation | negative regulation of gliogenesis | chromatin organization | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | positive regulation of cellular protein catabolic process | response to stimulus | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of oligodendrocyte progenitor proliferation | cellular response to hypoxia | response to stress | regulation of cell proliferation | positive regulation of proteolysis involved in cellular protein catabolic process | positive regulation of proteolysis | regulation of DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | protein deacetylase activity | macromolecule modification | histone H3 deacetylation | regulation of nucleic acid-templated transcription | organelle assembly | system development | response to oxygen levels | nitrogen compound metabolic process | multicellular organism development | NAD-dependent protein deacetylase activity | cellular response to oxidative stress | regulation of gene expression | histone deacetylase activity | cellular response to stress | cell projection assembly | positive regulation of cellular metabolic process | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | negative regulation of oligodendrocyte progenitor proliferation | response to oxidative stress | protein deacetylation | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | response to caloric restriction | negative regulation of autophagy | NAD-dependent histone deacetylase activity | regulation of cellular metabolic process | regulation of protein metabolic process | histone H4 deacetylation | regulation of RNA metabolic process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of execution phase of apoptosis | protein metabolic process | NAD-dependent histone deacetylase activity (H4-K16 specific) | anatomical structure development | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | regulation of DNA-templated transcription in response to stress | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | cellular response to caloric restriction | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | positive regulation of cell death | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | cilium assembly | positive regulation of programmed cell death | negative regulation of transcription from RNA polymerase II promoter in response to stress | positive regulation of binding | cilium organization | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of gliogenesis | covalent chromatin modification | regulation of transcription, DNA-templated | positive regulation of DNA binding | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of nervous system development | regulation of developmental process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | negative regulation of neural precursor cell proliferation | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | chromosome organization | regulation of execution phase of apoptosis | cellular metabolic process | regulation of cell death | negative regulation of cell death | negative regulation of cell development | regulation of ubiquitin-dependent protein catabolic process | negative regulation of cell differentiation | negative regulation of reactive oxygen species metabolic process | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process
GO Cellular Component
chromosome | centriole | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | microtubule organizing center | paranode region of axon | cell body | cell | nuclear lumen | neuronal cell body | compact myelin | cytoplasm | spindle | intracellular organelle | meiotic spindle | main axon | centrosome | cell-cell junction | glial cell projection | cell projection | perikaryon | midbody | chromatin | nuclear chromosome | perinuclear region of cytoplasm | microtubule cytoskeleton | juxtaparanode region of axon | membrane-bounded organelle | heterochromatin | nucleus | organelle | nuclear heterochromatin | axon | membrane-enclosed lumen | paranodal junction | nuclear chromatin | Schmidt-Lanterman incisure | cytosol | cytoskeleton | intracellular | cell junction | myelin sheath | mitotic spindle
