QuickView for golf;jsessionid=180901A1423E412F84C21F46071AE9C5;jsessionid=29CB89E0F1EE191928813277D8E5254B (gene)
- Gene Symbol:
- GNAL
Homo sapiens - Full name:
- G protein subunit alpha L
- Synonyms:
- DYT25, guanine nucleotide-binding protein G(olf) subunit alpha, adenylate cyclase-stimulating G alpha protein, olfactory type, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide, olfactory type
- Genomic Location:
- Chr 18: 11679263-11871922
- Description:
-
This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibil...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Pan troglodytes , Gallus gallus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
18p11.21
| Transcripts Names |
|---|
| NM_002071 |
| NM_182978 |
| NM_001142339 |
| NM_001261443 |
| NM_001261444 |
| XM_006722324 |
| XM_024451164 |
GO Molecular Function
guanyl ribonucleotide binding | ribonucleoside binding | cation binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | hydrolase activity | G-protein beta/gamma-subunit complex binding | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | G-protein coupled receptor binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
intracellular signal transduction | cellular process | regulation of cellular process | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | response to stimulus | G-protein coupled receptor signaling pathway | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | nervous system process | second-messenger-mediated signaling | cell communication | cyclic-nucleotide-mediated signaling | cAMP-mediated signaling | sensory perception | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | signaling | sensory perception of chemical stimulus | sensory perception of smell | signal transduction | multicellular organismal process
GO Cellular Component
heterotrimeric G-protein complex | cytoplasmic side of plasma membrane | catalytic complex | extrinsic component of membrane | cell | cytoplasmic side of membrane | plasma membrane protein complex | extrinsic component of plasma membrane | protein-containing complex | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | intracellular | membrane
